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Le fluconazole, commercialisé sous le nom de Diflucan, est un antifongique appartenant à la classe des triazolés. Son action repose sur l’inhibition de la 14α-déméthylase dépendante du cytochrome P450, empêchant la conversion du lanostérol en ergostérol, composant essentiel de la membrane fongique. Cette inhibition fragilise la membrane et conduit à la mort cellulaire. La biodisponibilité du fluconazole est élevée (90 %), avec une pénétration efficace dans le liquide céphalorachidien, ce qui justifie son utilisation dans les méningites cryptococciques. Sa demi-vie longue permet des administrations espacées. Les données cliniques soulignent son rôle dans la prise en charge des candidoses systémiques, des candidémies et des infections opportunistes chez les sujets immunodéprimés. Les références thérapeutiques indiquent que diflucan prix est intégré dans de nombreux protocoles, tout en rappelant la surveillance nécessaire des enzymes hépatiques et les interactions avec les substrats du CYP3A4 et du CYP2C9.
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Country: 83.140.155.4, Europe, SE
City: 18.056 , Sweden
I've used Bluetooth for about 9 years...I researched just a bit when I bought my first one and settled on Plantronics and have used nothing else since. The dependability is off the scale...I'm 50 years old and go from one minute wrestling with 2, 3, and 5 year old grandsons to crawling under and working on cars or playing tackle football with kids 1/3 my age the next and have countless times forgot to that I had it on...It takes a beating....I'm also a 29 year (and counting veteran police officer) at a tiny 6 man PD in southwest Indiana, 15 miles away from nearest other law enforcement, and we almost always work with just one guy on....I've talked with 911 dispatchers while crawled up inside an inverted car on the highway; I've stayed on with my local dispatchers while breaking up and being in fights; and have got real time to & from dispatchers and other officers on the phone so that nothing was broadcast over scanners on the way to intense/serious calls AND, most importantly, so I could keep both hands on the wheel when driving hard....There's also been many times when I've been on my way to a call and be driving with one hand, talking to dispatch on my car radio with the other, and talking to a 911 dispatcher or victim or another officer all at the same time....AND all because of a PLANTRONICS Pro, then a Pro HD, and now the PLANTRONICS LEGEND....Testament that these things are the best sound quality and most durable Bluetooth that you can buy...There's been MANY work situations that this Plantronics Legend has been responsible for allowing me to go back home and get back to those football games and wrestling matches... :)
Critics and audiences are hailing the restoration of this now cult-classic. The stream of consciousness writing style that Dr. Rand pioneered in this daring work was soon picked up by Jack Kerouac and other writers of the beat generation. One can't help but visualize the thick haze of cigarette smoke and booze as Rand would read aloud his digits to a mesmerizing bongo drum beat while cool chicks prance so sleak. So hip, 45635, yeah, 34534, 76567, that's it.
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These gloves are comfortable and offer sufficient hand protection from blisters and rough surface on the trail. Listened to other reviewers and purchased larger size; great decision.