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Le fluconazole, commercialisé sous le nom de Diflucan, est un antifongique appartenant à la classe des triazolés. Son action repose sur l’inhibition de la 14α-déméthylase dépendante du cytochrome P450, empêchant la conversion du lanostérol en ergostérol, composant essentiel de la membrane fongique. Cette inhibition fragilise la membrane et conduit à la mort cellulaire. La biodisponibilité du fluconazole est élevée (90 %), avec une pénétration efficace dans le liquide céphalorachidien, ce qui justifie son utilisation dans les méningites cryptococciques. Sa demi-vie longue permet des administrations espacées. Les données cliniques soulignent son rôle dans la prise en charge des candidoses systémiques, des candidémies et des infections opportunistes chez les sujets immunodéprimés. Les références thérapeutiques indiquent que diflucan prix est intégré dans de nombreux protocoles, tout en rappelant la surveillance nécessaire des enzymes hépatiques et les interactions avec les substrats du CYP3A4 et du CYP2C9.

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    Country: 46.234.102.5, Europe, CZ

    City: 14.4112 , Czechia

  • Oldtymr46 - Could be better

    Brings back memories of my old Gerber guardian, except for this NASTY PLASTIC CASE. 27 yrs in the army (infantry) and my old Gerber was right there with me until I retired in 93 then it went to my grandson who now carries it proudly OVER THERE! I'll be looking to replace the case.Oh by the way this thing wouldn't cut butter,GERBER HAS REALLY WENT DOWN HILL!

  • Amazon Customer - and can't claim better focus or memory

    Ran through a 30 count, and can't claim better focus or memory. Not sure if there is a 'build up period' (as in you need 2 months worth before you feel increase focus/memory), but 30 pills taken as directed did not provide me any noticeable changes.