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Le fluconazole, commercialisé sous le nom de Diflucan, est un antifongique appartenant à la classe des triazolés. Son action repose sur l’inhibition de la 14α-déméthylase dépendante du cytochrome P450, empêchant la conversion du lanostérol en ergostérol, composant essentiel de la membrane fongique. Cette inhibition fragilise la membrane et conduit à la mort cellulaire. La biodisponibilité du fluconazole est élevée (90 %), avec une pénétration efficace dans le liquide céphalorachidien, ce qui justifie son utilisation dans les méningites cryptococciques. Sa demi-vie longue permet des administrations espacées. Les données cliniques soulignent son rôle dans la prise en charge des candidoses systémiques, des candidémies et des infections opportunistes chez les sujets immunodéprimés. Les références thérapeutiques indiquent que diflucan prix est intégré dans de nombreux protocoles, tout en rappelant la surveillance nécessaire des enzymes hépatiques et les interactions avec les substrats du CYP3A4 et du CYP2C9.

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  • R. M. - "You've been a bad boy!"

    Can movies have ingredients? This one has cheese in it. It is so cheesy, I found myself laughing. It's really something Mystery Science Theater 3000 would have a field day with. Don't watch it expecting to be frightened..Muhahahaha!

  • Dr. Bob - One Amazed Skeptic!

    I'm an ER doctor. Not the usual herbal remedy kind of guy. My wife had a nail fungus and didn't tell me about it. I saw it and told her to go to the Dermatologist. She refused b/c she thought they would remove her nail - and her daughter was getting married in a month. So I looked on Amazon and took a chance on this. Wow, I'm shocked. It actually worked. It takes awhile, but it does. She just uses a Q-Tip and applies it directly each night. Smells to high heaven, but does the trick. Highly recommended.

  • I.A. - Overall it's good and will help you learn and practice but don't ...

    I found it awkward that the strings are mirrored. Even if I change the settings it still feels uncomfortable. There is a large library of songs included but all very old. Overall it's good and will help you learn and practice but don't expect miracles.