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Le fluconazole, commercialisé sous le nom de Diflucan, est un antifongique appartenant à la classe des triazolés. Son action repose sur l’inhibition de la 14α-déméthylase dépendante du cytochrome P450, empêchant la conversion du lanostérol en ergostérol, composant essentiel de la membrane fongique. Cette inhibition fragilise la membrane et conduit à la mort cellulaire. La biodisponibilité du fluconazole est élevée (90 %), avec une pénétration efficace dans le liquide céphalorachidien, ce qui justifie son utilisation dans les méningites cryptococciques. Sa demi-vie longue permet des administrations espacées. Les données cliniques soulignent son rôle dans la prise en charge des candidoses systémiques, des candidémies et des infections opportunistes chez les sujets immunodéprimés. Les références thérapeutiques indiquent que diflucan prix est intégré dans de nombreux protocoles, tout en rappelant la surveillance nécessaire des enzymes hépatiques et les interactions avec les substrats du CYP3A4 et du CYP2C9.

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    Country: 114.55.41.39, Asia, CN

    City: 120.1614 Zhejiang, China

  • Amazon Customer - Waiting

    I wa s skeptical about buying this product. But after reading all these reviews, I am excited to receive this product.

  • William Goodwin - Good, BIG, book.

    This is a huge book, but it is well organized and has a good index. So far, I've been able to find the answers to all my questions about using Excel 2013. Finding the answers takes careful reading and trying the examples, but I do find them. I think it's a good book for one who wants to get the most out of Excel 2013.

  • Nurse_going_natural - Really elevated mood and helped during SSRI withdrawal.

    So I figure since I so heavily rely on Amazon reviews, I could at least start reviewing some of the items I have picked up on my latest shopping spree. Niacin from twin labs has gone above and beyond my expectations. I have been on it for over 5 weeks now, just went through my first bottle. I started on 500mg a day and immediately got the intense flush. I am now up to 2000mg a day. I have to say, within 2 weeks my mood improved TREMENDOUSLY. Things that used to irritate me I was, for the first time in my life, able to just brush it off. It REALLY helped my mood to stabilize and be more cheery overall. My mom and fiance both noticed the difference, and I found it so easy to be NICE for once. Now, because it was working so well and my mood was so great, I decided to discontinue my SSRI medication. Let me tell you, it has been a rough few weeks! My mood is more scattered, but I know that this is at least helping me to continue to function and keep my head above water even with the withdrawal side effects. The price is great, next time I order it I will order the 1000mg tablets. The flush is a little scary the first time, but you get used to it. I really urge you to consider this product if you feel like you're swimming in frustration and your mood just won't level, just be sure to stick with it. I have taken it every day without fail. Also, everyone is noticing how smooth and nice my skin looks, an added bonus!

  • R. Kepler - Absolutely perfect fit on my 2014 C-Max Energi

    Absolutely perfect fit on my 2014 C-Max Energi. Total sun protection with the only issue being it's a bit large when rolled up, but it's worth it to have the sun and heat protection. Ordered one for my Super Duty hoping it's just as good a fit.