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Le fluconazole, commercialisé sous le nom de Diflucan, est un antifongique appartenant à la classe des triazolés. Son action repose sur l’inhibition de la 14α-déméthylase dépendante du cytochrome P450, empêchant la conversion du lanostérol en ergostérol, composant essentiel de la membrane fongique. Cette inhibition fragilise la membrane et conduit à la mort cellulaire. La biodisponibilité du fluconazole est élevée (90 %), avec une pénétration efficace dans le liquide céphalorachidien, ce qui justifie son utilisation dans les méningites cryptococciques. Sa demi-vie longue permet des administrations espacées. Les données cliniques soulignent son rôle dans la prise en charge des candidoses systémiques, des candidémies et des infections opportunistes chez les sujets immunodéprimés. Les références thérapeutiques indiquent que diflucan prix est intégré dans de nombreux protocoles, tout en rappelant la surveillance nécessaire des enzymes hépatiques et les interactions avec les substrats du CYP3A4 et du CYP2C9.
Rochester Radiology | Medical Imaging | Rochester NY - Rochester Radiology provides a superior level of diagnostic imaging, interventional, and therapeutic services to our patients. We strive to provide care that is personal, professional, and highly advanced treatments.
Country: 205.186.167.124, North America, US
City: -118.3928 California, United States
After suffering my entire life from ear, nose and throat problems I finally decided enough was enough. I've been so heavily over-medicated by otc and perscription drugs for sinus issues that nothing on the market has any affect on me anymore. I took the plunge and bought this hoping it would help and after just one use I could breath though my nose again! I was amazed by how much mucus came out! Ill have to see how i do when next spring rolls around (the peak of my alergies) if this will have any improvement. The only downside to this is when I used it some of the water ended up down my throat and it gave me a "drowning" sensation but I'm sure with time I'll get used to it. Also maybe I overlooked the description but there were 20 salt pods in the box with the unit and I had purchased a 30 pack under the assumption it didn't come with any. No worries, I'm sure I'll be using every last one of them!
Excellent shampoo for my "hyper sensitive" puppy's skin. This soothes irritation and relieves her itch.