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Le fluconazole, commercialisé sous le nom de Diflucan, est un antifongique appartenant à la classe des triazolés. Son action repose sur l’inhibition de la 14α-déméthylase dépendante du cytochrome P450, empêchant la conversion du lanostérol en ergostérol, composant essentiel de la membrane fongique. Cette inhibition fragilise la membrane et conduit à la mort cellulaire. La biodisponibilité du fluconazole est élevée (90 %), avec une pénétration efficace dans le liquide céphalorachidien, ce qui justifie son utilisation dans les méningites cryptococciques. Sa demi-vie longue permet des administrations espacées. Les données cliniques soulignent son rôle dans la prise en charge des candidoses systémiques, des candidémies et des infections opportunistes chez les sujets immunodéprimés. Les références thérapeutiques indiquent que diflucan prix est intégré dans de nombreux protocoles, tout en rappelant la surveillance nécessaire des enzymes hépatiques et les interactions avec les substrats du CYP3A4 et du CYP2C9.
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Country: 31.31.72.21, Europe, CZ
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I just love the choreographies and the menus and dance options. And most of the songs are really fun to play.
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The description of the book was correct. The book was in great condition and was mailed out timely. In fact, I received the book sooner then promised. I like the way I was able to track the book during the mailing process.
I was so excited when the tray came out for the Cruz as my lo is 8 mos old and loves to have snacks! But when we received it and attached it to the stroller, it is so high that he has to reach up to touch the tray. Are we doing something wrong? We attached it where it shows on the box so we think we're doing it right. If we did it right then why is the tray so high? He may not be able to use it until he's older and taller.
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