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Le fluconazole, commercialisé sous le nom de Diflucan, est un antifongique appartenant à la classe des triazolés. Son action repose sur l’inhibition de la 14α-déméthylase dépendante du cytochrome P450, empêchant la conversion du lanostérol en ergostérol, composant essentiel de la membrane fongique. Cette inhibition fragilise la membrane et conduit à la mort cellulaire. La biodisponibilité du fluconazole est élevée (90 %), avec une pénétration efficace dans le liquide céphalorachidien, ce qui justifie son utilisation dans les méningites cryptococciques. Sa demi-vie longue permet des administrations espacées. Les données cliniques soulignent son rôle dans la prise en charge des candidoses systémiques, des candidémies et des infections opportunistes chez les sujets immunodéprimés. Les références thérapeutiques indiquent que diflucan prix est intégré dans de nombreux protocoles, tout en rappelant la surveillance nécessaire des enzymes hépatiques et les interactions avec les substrats du CYP3A4 et du CYP2C9.
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Country: 104.31.88.24, North America, US
City: -122.3933 California, United States
got original. registered online with sage itself. bought for a customer. knew what i wanted so i am please to get it as advertised. as always, amazons price is the best
Perfect fit for our 2011 F-150. Watertight like expected. Easy to put on and take off. Good added security - as long as the tailgate is locked, somebody would have to try pretty hard to get into the back of our truck. We bought this so that we could drive our truck for road trips. I felt completely comfortable parked at a hotel parking lot knowing everything in the back of the truck was safe.
It is what it is... A disaster movie with a script that seems like it was written by a high school acting class. How it plays out on the screen is great and exciting, but when the actors start talking, yuck. But the special effects extravaganza is great fun to watch. I know...it's a disaster movie with lots of death and destruction and mayhem, etc. But that is what I pay the money for. If only the scripts for these kinds of movies would be of better quality then everyone would be happier. But it is what it is....a disaster movie.