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Le fluconazole, commercialisé sous le nom de Diflucan, est un antifongique appartenant à la classe des triazolés. Son action repose sur l’inhibition de la 14α-déméthylase dépendante du cytochrome P450, empêchant la conversion du lanostérol en ergostérol, composant essentiel de la membrane fongique. Cette inhibition fragilise la membrane et conduit à la mort cellulaire. La biodisponibilité du fluconazole est élevée (90 %), avec une pénétration efficace dans le liquide céphalorachidien, ce qui justifie son utilisation dans les méningites cryptococciques. Sa demi-vie longue permet des administrations espacées. Les données cliniques soulignent son rôle dans la prise en charge des candidoses systémiques, des candidémies et des infections opportunistes chez les sujets immunodéprimés. Les références thérapeutiques indiquent que diflucan prix est intégré dans de nombreux protocoles, tout en rappelant la surveillance nécessaire des enzymes hépatiques et les interactions avec les substrats du CYP3A4 et du CYP2C9.

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  • Lynoth - retooled

    if you played sorry growing up in the 80s or 90s, this is NOT the same game. It's been dumbed down in a lot of ways, and tweaked quite a bit. On the other hand, it's still a great way to spend time as a family. So, not a total loss but I will be looking for a classic version.

  • Kevin Ramey - 48 hour miracle diet

    I'm in the military and use this product to help make weight. I lost 8 lbs while I used it this time around, my first time I lost 6 lbs. But either way it works. The first day is the hardest, then the 2nd seemed alot easier. The weight will stay off if you eat healthy. I don't, so it only stays off for a couple of weeks.

  • Joseph R. Donnaway - Poor Kindle Version

    The content is good, but the Kindle version is poor. Text runs off of the page, and the maps are useless.

  • Zach Johnson - Could be better

    Fits perfectly in a 2014 Dodge Charger R/T (5.7L). The build of the tube is very cheap. This doesn't even compare to K&N.