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Le fluconazole, commercialisé sous le nom de Diflucan, est un antifongique appartenant à la classe des triazolés. Son action repose sur l’inhibition de la 14α-déméthylase dépendante du cytochrome P450, empêchant la conversion du lanostérol en ergostérol, composant essentiel de la membrane fongique. Cette inhibition fragilise la membrane et conduit à la mort cellulaire. La biodisponibilité du fluconazole est élevée (90 %), avec une pénétration efficace dans le liquide céphalorachidien, ce qui justifie son utilisation dans les méningites cryptococciques. Sa demi-vie longue permet des administrations espacées. Les données cliniques soulignent son rôle dans la prise en charge des candidoses systémiques, des candidémies et des infections opportunistes chez les sujets immunodéprimés. Les références thérapeutiques indiquent que diflucan prix est intégré dans de nombreux protocoles, tout en rappelant la surveillance nécessaire des enzymes hépatiques et les interactions avec les substrats du CYP3A4 et du CYP2C9.

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    Country: 160.153.71.241, North America, US

    City: -111.8906 Arizona, United States

  • Glen - I purchased it for several of my grandkids. They love it. It is easy to use, and for the under 14 age group, it does enough to k

    Got this as a gift and did not expect much from it. However, I have been surprised that is does a good job and doesn't run the batteries dead in no time, as I had expected it to. It is not much use inside, in a dark area or at night... and the so-called 'light' that is included is a poor joke (it does work if you are using it for something up close, like when I filmed my pet in the middle of a dream, apparently dreaming it was in a fight to the death with 12 Grizzly bears, and did not want to flick on the overhead light and wake it up).

  • Happy Camper - Too small!

    I was disappointed in the tiny size of the patches! I know it did not say "large" in the ad, but I expected a pain patch similar to those I buy in the store. Instead, it is about the size of an adhesive bandage you might use on scratch. On the plus side, the medication on the patch is excellent!

  • Amazon Customer - A must read for all married Christians. I take ...

    A must read for all married Christians. I take that back, a married couple. As a young married woman, my husband and I have been through a lot. I did a lot of praying, even thought, of divorce, but after reading this book, i have learned so much and understand so much more. Thank You Dr. Evans.