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Le fluconazole, commercialisé sous le nom de Diflucan, est un antifongique appartenant à la classe des triazolés. Son action repose sur l’inhibition de la 14α-déméthylase dépendante du cytochrome P450, empêchant la conversion du lanostérol en ergostérol, composant essentiel de la membrane fongique. Cette inhibition fragilise la membrane et conduit à la mort cellulaire. La biodisponibilité du fluconazole est élevée (90 %), avec une pénétration efficace dans le liquide céphalorachidien, ce qui justifie son utilisation dans les méningites cryptococciques. Sa demi-vie longue permet des administrations espacées. Les données cliniques soulignent son rôle dans la prise en charge des candidoses systémiques, des candidémies et des infections opportunistes chez les sujets immunodéprimés. Les références thérapeutiques indiquent que diflucan prix est intégré dans de nombreux protocoles, tout en rappelant la surveillance nécessaire des enzymes hépatiques et les interactions avec les substrats du CYP3A4 et du CYP2C9.
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Country: 83.140.155.4, Europe, SE
City: 18.056 , Sweden
Great product. I felt today on my way to classes and they saved my hands from what could have been a very bad graze! They handle the damage better than I expected considering that the accident occurred on the street; only poked a little hole on the right glove.
I expected this to have the recepies that normal people eat, like Norway Roof Rat, robin, cardinal, and other backyard birds,or even kittens and puppies but I was disapointed because it was about things that rich people buy at the store like cow meat and chickens.