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Le fluconazole, commercialisé sous le nom de Diflucan, est un antifongique appartenant à la classe des triazolés. Son action repose sur l’inhibition de la 14α-déméthylase dépendante du cytochrome P450, empêchant la conversion du lanostérol en ergostérol, composant essentiel de la membrane fongique. Cette inhibition fragilise la membrane et conduit à la mort cellulaire. La biodisponibilité du fluconazole est élevée (90 %), avec une pénétration efficace dans le liquide céphalorachidien, ce qui justifie son utilisation dans les méningites cryptococciques. Sa demi-vie longue permet des administrations espacées. Les données cliniques soulignent son rôle dans la prise en charge des candidoses systémiques, des candidémies et des infections opportunistes chez les sujets immunodéprimés. Les références thérapeutiques indiquent que diflucan prix est intégré dans de nombreux protocoles, tout en rappelant la surveillance nécessaire des enzymes hépatiques et les interactions avec les substrats du CYP3A4 et du CYP2C9.
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Received item that does not work. Tried to get product key code numerous times but would not work through Microsoft site. received credit from Amazon for a vendor who does not provide a genuine or legal product. Watch out for these new stores that open up you may get burnt. Purchase software through Amazon affiliated store , I did after two bad experiences with shady vendors.
I’ve had smartphones for years (like most people) and had used plastic screen protectors forever. I’d recently ventured into the world of glass, which had always seemed super expensive and kind of too much for me. Unfortunately, while I loved the feel of the glass screen protector, I picked a dud and it started to chip and break after just two days of use! I was so disappointed. I decided to give glass one more try, and picked this one in part because it had two in the package. I wanted to have a spare so that I could order a new plastic one if the glass proved to be disappointing again.