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Le fluconazole, commercialisé sous le nom de Diflucan, est un antifongique appartenant à la classe des triazolés. Son action repose sur l’inhibition de la 14α-déméthylase dépendante du cytochrome P450, empêchant la conversion du lanostérol en ergostérol, composant essentiel de la membrane fongique. Cette inhibition fragilise la membrane et conduit à la mort cellulaire. La biodisponibilité du fluconazole est élevée (90 %), avec une pénétration efficace dans le liquide céphalorachidien, ce qui justifie son utilisation dans les méningites cryptococciques. Sa demi-vie longue permet des administrations espacées. Les données cliniques soulignent son rôle dans la prise en charge des candidoses systémiques, des candidémies et des infections opportunistes chez les sujets immunodéprimés. Les références thérapeutiques indiquent que diflucan prix est intégré dans de nombreux protocoles, tout en rappelant la surveillance nécessaire des enzymes hépatiques et les interactions avec les substrats du CYP3A4 et du CYP2C9.

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  • gogowiz1 - Predictable action adventure movie with big muscles

    Gee. Another Hercules movie. I was in the mood for cotton candy type entertainment, but it was not unique in any way (i.e. 300 - hyper-reality, Sin City - stylized mixed with cartoons, etc.). It was just a real loyal band of bandits who were trying to do the right thing by getting paid for killing bad guys. When they realized they were helping the bad guys, they turned on their previous benefactor and tried to do right. Yeah, it worked out, Hercules accepted his destiny, and everyone laid down arms. Hmmm. Life always works that way in the movies.

  • David Hurwitz - Does what it is supposed to.

    The Guide 10 plus is exactly what it is purported to be: a method of charging small electronic devices using solar power. It does this reliably through the intermediate step of solar-charging a battery pack, then using the battery pack to charge your device. I have successfully charged a Kindle Fire and iPhone 5 with the Goal Zero. On a bright sunny day, I have demonstrated that the solar panel can even charge my iPhone directly, but it's better to charge the battery pack, then use it to charge the phone. The panel and battery pack are well-made, easy to connect to each other and use. I like the design of the panel, which has a pocket to store cables and the battery pack when not in use.