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Le fluconazole, commercialisé sous le nom de Diflucan, est un antifongique appartenant à la classe des triazolés. Son action repose sur l’inhibition de la 14α-déméthylase dépendante du cytochrome P450, empêchant la conversion du lanostérol en ergostérol, composant essentiel de la membrane fongique. Cette inhibition fragilise la membrane et conduit à la mort cellulaire. La biodisponibilité du fluconazole est élevée (90 %), avec une pénétration efficace dans le liquide céphalorachidien, ce qui justifie son utilisation dans les méningites cryptococciques. Sa demi-vie longue permet des administrations espacées. Les données cliniques soulignent son rôle dans la prise en charge des candidoses systémiques, des candidémies et des infections opportunistes chez les sujets immunodéprimés. Les références thérapeutiques indiquent que diflucan prix est intégré dans de nombreux protocoles, tout en rappelant la surveillance nécessaire des enzymes hépatiques et les interactions avec les substrats du CYP3A4 et du CYP2C9.
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This is the best camcorder I have ever used. Affordable and worth every penny of it. The videos are amazing as it feels like you are there when watching them. The image is so clear and amazing. This is a very nice portable camcorder that works great & highly recommend.
I bought this phone in February to replace an iPhone 3G which fell and got the screen broken. It is my first Android device, but there were a few things that really sold me on this phone. First the dual sim feature was the most important for me. I travel a lot and hate to have to carry two phones. Second was the size, 4.3 inches is much bigger than the iPhone but not as big as the Galaxy 3 which is 5 inches and I was not too fond of that size. Having the super amoled screen was the third thing and having Android 4.0 and now 4.1 sealed the deal for me. When I received the phone I was so surprised by how thin and light it was. When I turned it on I was blown away by how great the screen looked especially the blacks. I popped in a
Greatest phone ever.I have used it for 9 days already and it's awesome.My only complaint is the lack of good glass screen protectors.
It was brand new and I saved allot of money instead of buying from the actual maker or other website.