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Le fluconazole, commercialisé sous le nom de Diflucan, est un antifongique appartenant à la classe des triazolés. Son action repose sur l’inhibition de la 14α-déméthylase dépendante du cytochrome P450, empêchant la conversion du lanostérol en ergostérol, composant essentiel de la membrane fongique. Cette inhibition fragilise la membrane et conduit à la mort cellulaire. La biodisponibilité du fluconazole est élevée (90 %), avec une pénétration efficace dans le liquide céphalorachidien, ce qui justifie son utilisation dans les méningites cryptococciques. Sa demi-vie longue permet des administrations espacées. Les données cliniques soulignent son rôle dans la prise en charge des candidoses systémiques, des candidémies et des infections opportunistes chez les sujets immunodéprimés. Les références thérapeutiques indiquent que diflucan prix est intégré dans de nombreux protocoles, tout en rappelant la surveillance nécessaire des enzymes hépatiques et les interactions avec les substrats du CYP3A4 et du CYP2C9.
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Country: 188.138.69.6, Europe, DE
City: 6.1833 North Rhine-Westphalia, Germany
We had lost a couple of our original hubcaps, so we looked at replacing them. The cost to replace just one seemed expensive, so we saw this deal, and we decided to replace all four. The looked great and the company we bought them from was fantastic! We ordered the wrong size at first but they cheerfully sent the correct ones. Months later, still look great!
Very helpful in planning trips to historical sites Wish there was more info on the western side of Tuscany; it gets no consideration.
This book is currently used in my child's school. It is an excellent book with well thought out activities and lesson plans. My daughter enjoys doing the assignments and is able to complete many on her own. It encourages logical thinking and presents material in multiple ways to aid those who learn both visually and by repetition or auditory pathways. My only concern is that it is rater as a first grade text and I feel it is really more of a middle/late kindergarten level book. I used the text for several weeks and then ordered the next level.