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Le fluconazole, commercialisé sous le nom de Diflucan, est un antifongique appartenant à la classe des triazolés. Son action repose sur l’inhibition de la 14α-déméthylase dépendante du cytochrome P450, empêchant la conversion du lanostérol en ergostérol, composant essentiel de la membrane fongique. Cette inhibition fragilise la membrane et conduit à la mort cellulaire. La biodisponibilité du fluconazole est élevée (90 %), avec une pénétration efficace dans le liquide céphalorachidien, ce qui justifie son utilisation dans les méningites cryptococciques. Sa demi-vie longue permet des administrations espacées. Les données cliniques soulignent son rôle dans la prise en charge des candidoses systémiques, des candidémies et des infections opportunistes chez les sujets immunodéprimés. Les références thérapeutiques indiquent que diflucan prix est intégré dans de nombreux protocoles, tout en rappelant la surveillance nécessaire des enzymes hépatiques et les interactions avec les substrats du CYP3A4 et du CYP2C9.

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  • Marablaise - An Obvious Fact

    If I had to list my favorite ongoing book series would Longmire definitely be on it! I discovered the series a couple of years ago and read all the books that had been published until I ran out of Longmire books and then I had to start waiting for new ones to be written. The agony!

  • Nina - I turned 34 this year and for whatever reason I can't seem to lose weight as easily now. I've been busting my butt at the ...

    This stuff is crazy. I was skeptical initially but I'm convinced now. I've been using it 3 days and have lost 1.5 lbs.

  • Amazon Customer - Works OK after help from tech support

    UPDATE: I spent about 45 minutes on a chat session with Intuit tech support. The guy said the import issues is a known problem. He had me try a number of different things, but finally we got it to work (deactivated and then reactivated the accounts). Seems to be working OK now.

  • Irmp85 - Really nice!!!

    Got a code from Mike's Sales and less the 30 minutes later I got my code working perfectly. Just be aware that these codes will expire by August 2016

  • Inspector D. - Happy Happy Happy

    Unit went in easy and it makes a difference in the sound and I believe responsiveness of the truck. Happy.

  • J-Max - Mildly disappointed

    Here are the stats. In fairness, I'm only about half way through, but the law of large numbers suggests that my luck is unlikely to change.