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Le fluconazole, commercialisé sous le nom de Diflucan, est un antifongique appartenant à la classe des triazolés. Son action repose sur l’inhibition de la 14α-déméthylase dépendante du cytochrome P450, empêchant la conversion du lanostérol en ergostérol, composant essentiel de la membrane fongique. Cette inhibition fragilise la membrane et conduit à la mort cellulaire. La biodisponibilité du fluconazole est élevée (90 %), avec une pénétration efficace dans le liquide céphalorachidien, ce qui justifie son utilisation dans les méningites cryptococciques. Sa demi-vie longue permet des administrations espacées. Les données cliniques soulignent son rôle dans la prise en charge des candidoses systémiques, des candidémies et des infections opportunistes chez les sujets immunodéprimés. Les références thérapeutiques indiquent que diflucan prix est intégré dans de nombreux protocoles, tout en rappelant la surveillance nécessaire des enzymes hépatiques et les interactions avec les substrats du CYP3A4 et du CYP2C9.
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I Love netflix. I have it on my phone, tv, computer, and now....my tablet!! The only thing that could be better woul dbe if netflix was a little more current on recent movies out, but other than that, we love it!!!
Kids who don't have trampolines & whose parents can afford them are being neglected. Best money we've ever spent on a toy. Even our high schooler still loves it (this is our third trampoline... hard to move one across the country). No reason to buy one of those $1000 things when you can have this baby delivered right to your front door (where your kids can see it and spoil the Christmas surprise, but whatever. Maybe have it delivered to your neighbor, instead?) for about 1/4 the cost. Easy to assemble, light enough to move around so you can mow under it, and the mat around it seems to hold up well (we've had ours a year, still looks fairly new).
Wow what a beauty this thing possesses! i've seen some fancy hdmi cables but this diamond feature beats it all!
This item, as a gaming instrument, is a piece of shit. However, it is definitely a must-have for anyone cosplaying the Angry Video Game Nerd.