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Le fluconazole, commercialisé sous le nom de Diflucan, est un antifongique appartenant à la classe des triazolés. Son action repose sur l’inhibition de la 14α-déméthylase dépendante du cytochrome P450, empêchant la conversion du lanostérol en ergostérol, composant essentiel de la membrane fongique. Cette inhibition fragilise la membrane et conduit à la mort cellulaire. La biodisponibilité du fluconazole est élevée (90 %), avec une pénétration efficace dans le liquide céphalorachidien, ce qui justifie son utilisation dans les méningites cryptococciques. Sa demi-vie longue permet des administrations espacées. Les données cliniques soulignent son rôle dans la prise en charge des candidoses systémiques, des candidémies et des infections opportunistes chez les sujets immunodéprimés. Les références thérapeutiques indiquent que diflucan prix est intégré dans de nombreux protocoles, tout en rappelant la surveillance nécessaire des enzymes hépatiques et les interactions avec les substrats du CYP3A4 et du CYP2C9.

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  • Jersey Gal - Great for kids!!

    Loved it! My kids absolutely loved it. For reference they range from 4-8. We started watching them years ago on Disney and now try to get to their concerts. This new release was perfect for my daughters birthday!

  • Jerry - Just as good as the larger V-Cube

    I have bought the other larger v-cubes and was very happy with those, and have been checking with their website periodically for new cubes. The cube has the same solid feel to it as their larger cubes. I was also happy with the smoothness of the mechanism. I have 5x5 and 7x7 v-cubes and now a 3x3. I can;t wait for them to make 8x8 and 9x9!!!

  • Karen Rivera - Great Solar Lights Highly Recommended

    These work just as described and give me peace of mind by lighting the spots right outside my doorways that I need lit, without using electricity.These lights give off a nice warm glow and are easy to install.

  • Shannon's Kindle - Doesn't cover entire front surface of phone but neither do other brands apparently...

    Like many others have stated, the protector does not cover the entire surface of the phone. It is literally just big enough to cover the screen. I am disappointed it doesn't cover more, but after reading the reviews it sounds like all other brands are the exact same way. Hopefully companies will figure out a way to make them cover more of the front. Until then, I guess what I have is better than nothing! I will say installation of the protector was a breeze so that's a plus.

  • Amber G - Five Stars

    Ive lost 4lbs since taking this. Definitely works. I recieved this product at a discount for my honest review.