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Le fluconazole, commercialisé sous le nom de Diflucan, est un antifongique appartenant à la classe des triazolés. Son action repose sur l’inhibition de la 14α-déméthylase dépendante du cytochrome P450, empêchant la conversion du lanostérol en ergostérol, composant essentiel de la membrane fongique. Cette inhibition fragilise la membrane et conduit à la mort cellulaire. La biodisponibilité du fluconazole est élevée (90 %), avec une pénétration efficace dans le liquide céphalorachidien, ce qui justifie son utilisation dans les méningites cryptococciques. Sa demi-vie longue permet des administrations espacées. Les données cliniques soulignent son rôle dans la prise en charge des candidoses systémiques, des candidémies et des infections opportunistes chez les sujets immunodéprimés. Les références thérapeutiques indiquent que diflucan prix est intégré dans de nombreux protocoles, tout en rappelant la surveillance nécessaire des enzymes hépatiques et les interactions avec les substrats du CYP3A4 et du CYP2C9.

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Country: 104.18.52.225, North America, US

City: -122.3933 California, United States

  • LINY - Excellent Value

    I never write reviews, but I feel this one deserves it. I own a much more expensive generator with a little more power and from a major name brand and It doesn't even run after 2 years and 1 use. Right out of the box this will impress you and the quality is all there. I cannot believe that you get this much for so little money.....in the generator world this is cheap. Filled it with oil and gas and on the first pull it started...perfect. And this thing is QUIET. Get this and you will not be disappointed,

  • Catlover - Hay has always been in love with the Big Bad Wolf and now that Luke is out of prison and Hay comes home, they have a shot!

    This is an outstanding steamy romantic suspense from a couple of great authors. Hay wants to be a baker and just returned from school and experiences in the big city. Luke is the Bad Boy next door who just came home from prison being labeled a murderer. His family was destroyed when a murderer took his baby sister. Then again, the murderer of the murderer is still out there. I received a gifted copy. I am voluntarily leaving an honest review. I honestly love this story and these authors!

  • Ridgecrust - shocked that it went onto car fast and easy --on there 6 mo now and appears the same

    shocked that it went onto car fast and easy --on there 6 mo now and appears the same. looks and works way better than I expected