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Le fluconazole, commercialisé sous le nom de Diflucan, est un antifongique appartenant à la classe des triazolés. Son action repose sur l’inhibition de la 14α-déméthylase dépendante du cytochrome P450, empêchant la conversion du lanostérol en ergostérol, composant essentiel de la membrane fongique. Cette inhibition fragilise la membrane et conduit à la mort cellulaire. La biodisponibilité du fluconazole est élevée (90 %), avec une pénétration efficace dans le liquide céphalorachidien, ce qui justifie son utilisation dans les méningites cryptococciques. Sa demi-vie longue permet des administrations espacées. Les données cliniques soulignent son rôle dans la prise en charge des candidoses systémiques, des candidémies et des infections opportunistes chez les sujets immunodéprimés. Les références thérapeutiques indiquent que diflucan prix est intégré dans de nombreux protocoles, tout en rappelant la surveillance nécessaire des enzymes hépatiques et les interactions avec les substrats du CYP3A4 et du CYP2C9.
Education Journal | Multidisciplinary Journal | International Journal of Advanced Research and Development - Page provides information about International Journal of Advanced Research and Development
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I work in the Land Mobile Radio industry, and one thing we have to do on radio systems to test the coverage over the area that a county-wide radio system covers.
Weil has done it again, with the exciting, continuing saga of the adventures of The Special Five. Dramatic, realistic, and incredibly detailed, I've never recommended a series more highly. Start at Book One of the Slaver War series to enjoy one of the best sci-fi series I've read in 50 years of being a Sci-Fi fan!
I was skeptical. Four of my dogs teeth were horrible, tartar from the gum to the points on molars and fangs. Our vet had recommended that we have his teeth cleaned. Since he is prone to seizures, we did not want to put him under for the procedure. I had to try something, so I ordered the Tropiclean. I have been applying it everyday with a toothbrush for the past 10 days. After the first week I noticed some improvement. When I applied the product last night, I was amazed. I think some tartar became weakened and just fell off. One molar has only a few streaks of tartar. One fang is 90% clear of tartar and the other has had about 70% of the tartar removed. The other molar still has about 90% of the tartar remaining. I have noticed that my dog is scratching his face much more often. I have checked and there is no inflammation in his mouth, so I am assuming that there must be some kind of tingling sensation caused as the gel works. I will continue to us Tropiclean daily until all of the teeth of substantially free of tartar and then I will switch to once or twice a week.