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Le fluconazole, commercialisé sous le nom de Diflucan, est un antifongique appartenant à la classe des triazolés. Son action repose sur l’inhibition de la 14α-déméthylase dépendante du cytochrome P450, empêchant la conversion du lanostérol en ergostérol, composant essentiel de la membrane fongique. Cette inhibition fragilise la membrane et conduit à la mort cellulaire. La biodisponibilité du fluconazole est élevée (90 %), avec une pénétration efficace dans le liquide céphalorachidien, ce qui justifie son utilisation dans les méningites cryptococciques. Sa demi-vie longue permet des administrations espacées. Les données cliniques soulignent son rôle dans la prise en charge des candidoses systémiques, des candidémies et des infections opportunistes chez les sujets immunodéprimés. Les références thérapeutiques indiquent que diflucan prix est intégré dans de nombreux protocoles, tout en rappelant la surveillance nécessaire des enzymes hépatiques et les interactions avec les substrats du CYP3A4 et du CYP2C9.

AJMC - American Journal of Managed Care - The American Journal of Managed Care provides access to current, archived articles, supplements, as well as the latest articles on issues that managed care prof

  • http://www.ajmc.com/acocoalition ACO Coalition | AJMC - ACO and Emerging Healthcare Delivery Coalition</b> provides an engaging and interactive learning enviroment for ACO providers and leaders, payers, IDNs, specialty and retail pharmacy, GPO, national quality organizations, patient advocacy, employers, and pharmaceutical companies to collaborate regarding the current and evolving healthcare delivery models.
  • http://www.ajmc.com/contributor/vbid-center/2016/10/understanding-clinical-nuance Understanding Clinical Nuance - Clinical nuance is one of the core tenets of value-based insurance design, which is one possible solution to alleviate the financial burden Americans face as they are asked to pay a greater percentage of their healthcare expenditures.
  • http://www.ajmc.com/contributor/susan-kreimer/2016/10/barriers-to-acas-contraception-mandate-remain-part-ii Barriers to ACA’s Contraception Mandate Remain: Part II - For millions, the Affordable Care Act promised relief from the expenses of contraception. So why are many still not feeling it?
  • http://www.ajmc.com/contributor/vbid-center/2016/10/implementing-v-bid-in-medicare-and-medicare-advantage Implementing VBID in Medicare and Medicare Advantage - In current Medicare benefit designs, out-of-pocket costs do not reflect the expected clinical benefit or value of care. Research indicates that increasing patient cost sharing not only reduces the use of non-essential care, but also reduces the utilization of essential care.
  • http://www.ajmc.com/conferences/coa-payer-exchange-summit-2016/will-a-payer-provider-collaboration-guarantee-ocm-successs Will a Payer–Provider Collaboration Guarantee OCM Success? - At the Payer Exchange Summit V, sponsored by the Community Oncology Alliance, oncologists and payers came together to discuss the role of collaboration and data sharing for the successful implementation of the Oncology Care Model.
  • http://www.ajmc.com/conferences/coa-payer-exchange-summit-2016/strategies-for-ocm-implementation-at-the-coa-payer-summit Strategies for OCM Implementation at the COA Payer Summit - What are some of the challenges that clinical practices will face as they implement the Medicare Oncology Care Model (OCM)? What are some of the strategies that have worked for practices using similar payment models? These were some of the questions discussed at the Payer Exchange Summit V.

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