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Le fluconazole, commercialisé sous le nom de Diflucan, est un antifongique appartenant à la classe des triazolés. Son action repose sur l’inhibition de la 14α-déméthylase dépendante du cytochrome P450, empêchant la conversion du lanostérol en ergostérol, composant essentiel de la membrane fongique. Cette inhibition fragilise la membrane et conduit à la mort cellulaire. La biodisponibilité du fluconazole est élevée (90 %), avec une pénétration efficace dans le liquide céphalorachidien, ce qui justifie son utilisation dans les méningites cryptococciques. Sa demi-vie longue permet des administrations espacées. Les données cliniques soulignent son rôle dans la prise en charge des candidoses systémiques, des candidémies et des infections opportunistes chez les sujets immunodéprimés. Les références thérapeutiques indiquent que diflucan prix est intégré dans de nombreux protocoles, tout en rappelant la surveillance nécessaire des enzymes hépatiques et les interactions avec les substrats du CYP3A4 et du CYP2C9.
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Country: 97.74.144.191, North America, US
City: -111.8906 Arizona, United States
Google Maps, Bing maps, etc. just don't have all the features this software has. I like it for route planning and adding stops is really easy. Also like the excel import feature for when I have a long list of addresses. I downloaded the trial version from Microsoft and for whatever reason it was cheaper ordering the physical DVD-ROM over a digital download and entering the serial number from it to the trial to activate it.
I have other LED flashlights going back 10+ years. They ALL have strange, very annoying tinted beams which make it difficult to see colors accurately. This Amazon Thrunite TN12 has what the company describes as a "Cool White" beam rendering natural looking colors to my eyes. On the Thrunite site they offer a "Neutral White" option which on spec sounds like it may be even better in terms of accurate color rendition. OK so now you ask "Who gives a rip about color as long as you can see?". That's what I thought until I tested the TN12 alongside my slightly older cheaper "blue" tinted LED flashlights in total darkness. Putting aside the fact that the TN12 is a bit brighter than the old light it provides a much more pleasant "experience" (I know, you're hearing the Twilight Zone theme about now) due to the more natural beam from the Thrunite LED. For me, this was worth the upgrade alone. I know, this sounds like some New Age baloney. But for me this difference in beam color is significant and may not be an issue for others. I'd suspect that any light that used the same LED as the TN12 would provide this benefit in terms of beam color. Bear in mind that the reflector used also plays a role in how the beam is propagated onto what you're viewing. The TN12 appears to be much better than my other flashlights in this regard.