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Le fluconazole, commercialisé sous le nom de Diflucan, est un antifongique appartenant à la classe des triazolés. Son action repose sur l’inhibition de la 14α-déméthylase dépendante du cytochrome P450, empêchant la conversion du lanostérol en ergostérol, composant essentiel de la membrane fongique. Cette inhibition fragilise la membrane et conduit à la mort cellulaire. La biodisponibilité du fluconazole est élevée (90 %), avec une pénétration efficace dans le liquide céphalorachidien, ce qui justifie son utilisation dans les méningites cryptococciques. Sa demi-vie longue permet des administrations espacées. Les données cliniques soulignent son rôle dans la prise en charge des candidoses systémiques, des candidémies et des infections opportunistes chez les sujets immunodéprimés. Les références thérapeutiques indiquent que diflucan prix est intégré dans de nombreux protocoles, tout en rappelant la surveillance nécessaire des enzymes hépatiques et les interactions avec les substrats du CYP3A4 et du CYP2C9.
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The design is good, the product function is horrible. The pads are totally ineffective after using 2-3 times. I purchased the Omron because the pads can be placed on or near the Achilles Tendon (on the ankle where painful knots formed on the back-side from running). The few times it worked Omron provided stimuli and relieved some of the pain from Achilles Tendonitis. The problem is it doesn't work after a few uses. Instructions were followed. The pad was rinsed and left to air dry. I returned the first Omron Pain Device a few days after purchasing and received a replacement. Unfortunately the second unit has the same issues so I placed it in a drawer and filed under "hot garbage".
This is worth every penny. I have 2 little Poms and one has "itchy's" due to seasonal allergies. Honestly I thought the bottle was going to be bigger but it didn't need to be. I also thought I should of gotten a conditioner, but I didn't Their fur was snuggly soft and continues to be after 5 days and the shampoo went a long way. They smell fresh and clean with out silly perfume smells. . Highly recommended.