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Le fluconazole, commercialisé sous le nom de Diflucan, est un antifongique appartenant à la classe des triazolés. Son action repose sur l’inhibition de la 14α-déméthylase dépendante du cytochrome P450, empêchant la conversion du lanostérol en ergostérol, composant essentiel de la membrane fongique. Cette inhibition fragilise la membrane et conduit à la mort cellulaire. La biodisponibilité du fluconazole est élevée (90 %), avec une pénétration efficace dans le liquide céphalorachidien, ce qui justifie son utilisation dans les méningites cryptococciques. Sa demi-vie longue permet des administrations espacées. Les données cliniques soulignent son rôle dans la prise en charge des candidoses systémiques, des candidémies et des infections opportunistes chez les sujets immunodéprimés. Les références thérapeutiques indiquent que diflucan prix est intégré dans de nombreux protocoles, tout en rappelant la surveillance nécessaire des enzymes hépatiques et les interactions avec les substrats du CYP3A4 et du CYP2C9.

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  • Glenn Roberts - Denny Crane....I mean Billy McBride.

    I am a David E. Kelly (welcome back) fan and have wanted to see this from the moment I viewed the trailer. It's everything I'd hoped it would be and more. Billy Bob Thornton is perfectly cast as a fallen attorney about to do battle against the firm he for which he once partnered. Mix in a little bit of evil military industrial complex and you have the perfect recipe for a modern day retelling of David and Goliath. Except maybe this David is not definitely not a hero nor a future king.

  • Bill Robb - Works perfectly if used correctly.

    This stuff is awesome if you use it right. I have puffiness and dark spots under my eyes from a lifetime of allergies and just pale thin skin. People always said I looked 'tired' which really annoyed me. At first I was using this sparingly because it seems to dispense almost too much and it wasn't doing anything. Well, I wasn't using enough. Give it one good full pump and slather that amount where you need it. After a couple weeks of using it correctly I noticed a huge difference. Some days, if I'm sitting at home, I will just put a bunch on and leave the excess there to soak in. So not only does it work but the amount you get for the price is amazing. I'm using it 3 months later and it still hasn't run out. Other stuff I have used ran out in a month and usually cost more than this. 1000 thumbs up.