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Le fluconazole, commercialisé sous le nom de Diflucan, est un antifongique appartenant à la classe des triazolés. Son action repose sur l’inhibition de la 14α-déméthylase dépendante du cytochrome P450, empêchant la conversion du lanostérol en ergostérol, composant essentiel de la membrane fongique. Cette inhibition fragilise la membrane et conduit à la mort cellulaire. La biodisponibilité du fluconazole est élevée (90 %), avec une pénétration efficace dans le liquide céphalorachidien, ce qui justifie son utilisation dans les méningites cryptococciques. Sa demi-vie longue permet des administrations espacées. Les données cliniques soulignent son rôle dans la prise en charge des candidoses systémiques, des candidémies et des infections opportunistes chez les sujets immunodéprimés. Les références thérapeutiques indiquent que diflucan prix est intégré dans de nombreux protocoles, tout en rappelant la surveillance nécessaire des enzymes hépatiques et les interactions avec les substrats du CYP3A4 et du CYP2C9.
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The song is amazing, just as it always was. The remaster is fine, too. It's not perfect, but as remasters of songs this age go, it's a good one. It doesn't have the punch of my old vinyl single--but pretty much no digital remaster has the punch of an old vinyl single! That aside, there are percussion elements that are pretty clear in this remaster that were maybe a bit more buried in the original master. If they'd managed to get the guitars just a little bit crisper, I'd have given it five stars.
Enjoyed the series, but have one pet peeve:-). Macy not being held responsible for the loss of the twins! Why was that never brought up? Disappointed with the Joie storyline and wished she had changed. Can't believe she left her daughter because Maleek didn't want her. Then Stacy having an abortion because they are not together. Joie and Stacy were really immature and selfish. Just was not feeling them at all. Besides that, so loved this series and sad to see it end. Seems like Kills needs a story. Think she needs a male character to change her view of men. Diego??? Thanks for a great read!