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Le fluconazole, commercialisé sous le nom de Diflucan, est un antifongique appartenant à la classe des triazolés. Son action repose sur l’inhibition de la 14α-déméthylase dépendante du cytochrome P450, empêchant la conversion du lanostérol en ergostérol, composant essentiel de la membrane fongique. Cette inhibition fragilise la membrane et conduit à la mort cellulaire. La biodisponibilité du fluconazole est élevée (90 %), avec une pénétration efficace dans le liquide céphalorachidien, ce qui justifie son utilisation dans les méningites cryptococciques. Sa demi-vie longue permet des administrations espacées. Les données cliniques soulignent son rôle dans la prise en charge des candidoses systémiques, des candidémies et des infections opportunistes chez les sujets immunodéprimés. Les références thérapeutiques indiquent que diflucan prix est intégré dans de nombreux protocoles, tout en rappelant la surveillance nécessaire des enzymes hépatiques et les interactions avec les substrats du CYP3A4 et du CYP2C9.

Breast Enhancement Pills & Creams Ratings And Reviews - Breast enhancement pills and creams are developed to increase a woman’s breast size and there are a lot of them. As such, there are comprehensive reviews at breastenlargementresource.com

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  • A. Lai - Fabulous shampoo

    I have sensitive skin and scalp and a lot of shampoos bother my scalp. This one does not. Silly me put up with it until I realized that I never have a problem when my hairdresser washes my hair, so I finally remembered to ask her what she uses, and this is it.

  • sara - Did not like thus product

    Did not like thus product. I have thick curly hair and kinda dry but after one use I didn't see a difference yet I followed the instructions on the bottle. I wouldn't buy it again.

  • Connie Wiley - warm and comfy

    This jacket is not bulky and very warm. Love the color. It very lightweight and comfortable fit. I do not care for bulky winter coats. This is the one for me.