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Le fluconazole, commercialisé sous le nom de Diflucan, est un antifongique appartenant à la classe des triazolés. Son action repose sur l’inhibition de la 14α-déméthylase dépendante du cytochrome P450, empêchant la conversion du lanostérol en ergostérol, composant essentiel de la membrane fongique. Cette inhibition fragilise la membrane et conduit à la mort cellulaire. La biodisponibilité du fluconazole est élevée (90 %), avec une pénétration efficace dans le liquide céphalorachidien, ce qui justifie son utilisation dans les méningites cryptococciques. Sa demi-vie longue permet des administrations espacées. Les données cliniques soulignent son rôle dans la prise en charge des candidoses systémiques, des candidémies et des infections opportunistes chez les sujets immunodéprimés. Les références thérapeutiques indiquent que diflucan prix est intégré dans de nombreux protocoles, tout en rappelant la surveillance nécessaire des enzymes hépatiques et les interactions avec les substrats du CYP3A4 et du CYP2C9.

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    Country: 107.154.114.27, North America, US

    City: -122.2471 California, United States

  • Michael A. Honner - Merchant was good about returning it

    The unit overheated within ten minutes of use, become hot to the touch then shut down. Merchant was good about returning it ... Purchased this one instead which is working well ...

  • Robert S. Grossman - Just does not work well

    I purchased the NEAT scanner after hearing their radio ads. I finally set it up and gave it a shot. I do not recommend this device at all. The accuracy of their software is awful. First, I have to edit just about every document I scan in. It just seems that the software cannot recognize most documents. Second, it does not duplex documents. If you want to scan both sides you have to run the document through again. So you cannot scan a lot in at one time. Third, business cards really suck. Out of 40 cards I just scanned in as a test. The results were pretty bad. Just looking at the most basic simple cards, about 40% were unrecognizable and need to be completely entered manually. About 40% had multiple errors even with the most basic information like their name or state. The balance had slightly better results, but every card needs to be edited. Not a single card came in 100% accurate.

  • C. B - An absolute waste of my money

    I bought the peeler and the moisturizer. I received two peelers. One was sealed one wasn't. The unsealed container looks to have been used previously. The container was less than half full. The product inside was a dark color. It was thickly gelled. I'm not sure if that is the right consistency. I tested it in one spot and did not notice any difference. An absolute waste of my money.