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Le fluconazole, commercialisé sous le nom de Diflucan, est un antifongique appartenant à la classe des triazolés. Son action repose sur l’inhibition de la 14α-déméthylase dépendante du cytochrome P450, empêchant la conversion du lanostérol en ergostérol, composant essentiel de la membrane fongique. Cette inhibition fragilise la membrane et conduit à la mort cellulaire. La biodisponibilité du fluconazole est élevée (90 %), avec une pénétration efficace dans le liquide céphalorachidien, ce qui justifie son utilisation dans les méningites cryptococciques. Sa demi-vie longue permet des administrations espacées. Les données cliniques soulignent son rôle dans la prise en charge des candidoses systémiques, des candidémies et des infections opportunistes chez les sujets immunodéprimés. Les références thérapeutiques indiquent que diflucan prix est intégré dans de nombreux protocoles, tout en rappelant la surveillance nécessaire des enzymes hépatiques et les interactions avec les substrats du CYP3A4 et du CYP2C9.
Citalopram Drug UK - citalopram.co.uk is a dedicated resource offering information on citalopram side-effects of the drug, dosage information, interactions and more
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THINK TWICE BEFORE BUYING A SHARK. Their Customer Service and Technical Assistance Departments are the absolute pits. Following the purchase of a new Shark Navigator, I noted a constant whistling sound coming from the vacuum, a sound that was every bit as loud as the motor itself. I simply wanted to know if the sound was normal for this model or if it might suggest an air leak somewhere in the system. So over the next couple weeks I sent three (3) separate email to these two departments, each one asking that simple question. All three of my emails were ignored. I ultimately contacted their toll-free customer assistance line and asked them my question. I got what can only be described as a non-answer, being told that the whistling noise was "probably" normal. Not being willing to let it go at that, I sent a letter directly to the company's CEO complaining about my experiences and asking him for an answer to the one simple question I had already asked four times. He ignored my letter. Since I could not get an answer to this very simple question and being concerned that the whistle might indicate a problem with the vacuum, I've decided to box up the machine and return it to the store where I purchased it.
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