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Le fluconazole, commercialisé sous le nom de Diflucan, est un antifongique appartenant à la classe des triazolés. Son action repose sur l’inhibition de la 14α-déméthylase dépendante du cytochrome P450, empêchant la conversion du lanostérol en ergostérol, composant essentiel de la membrane fongique. Cette inhibition fragilise la membrane et conduit à la mort cellulaire. La biodisponibilité du fluconazole est élevée (90 %), avec une pénétration efficace dans le liquide céphalorachidien, ce qui justifie son utilisation dans les méningites cryptococciques. Sa demi-vie longue permet des administrations espacées. Les données cliniques soulignent son rôle dans la prise en charge des candidoses systémiques, des candidémies et des infections opportunistes chez les sujets immunodéprimés. Les références thérapeutiques indiquent que diflucan prix est intégré dans de nombreux protocoles, tout en rappelant la surveillance nécessaire des enzymes hépatiques et les interactions avec les substrats du CYP3A4 et du CYP2C9.

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Country: 192.185.137.137, North America, US

City: -95.4739 Texas, United States

  • Gerald Wood - Go for the Elephant!

    Goodness it doesn't hardly get any better than this perfume. It's like a Christmas Holiday following you around and making you feel happy without gaining the calories. Spicy, soft and well put together and others think so too!

  • Amazon Customer - Should be cheaper

    I rec'd this item from Spigen and in return i suppose to write a review on it. I have had now 4 different spigen cases (note 4, s5, note 5, and now the s7 edge). I am very impressed with the quality of product they have. When i came across the promotion for a free case i jumped on it! This case is a very good case in my opinion. Seems have good quality leather, the cut outs are perfectly placed with plenty of room for the plugs to fit, the magnet is strong, and the money and card holder are good too! The cut out on the front to allow you to still hear the call with the cover closed is great too! The reason for not giving 4 or 5 stars is this: i purchased a different case made by a different manufacture for my mothers s7 edge and it came in multiple colors and was a lot cheaper in price. The retail price for the spigen case is 24.99 and the mazon price is 16.99. I paid 8.99 for the competitors case and the only difference is, the 8.99 case doesnt have the cut out on the cover of the case to listen to phone calls while it is closed. The quality is the same and the other company has multiple colors (7 to choose from). So im not saying i wouldnt recommend the spigen case, i guess what i am suggesting is spigen should make more colors and drop the price.