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Le fluconazole, commercialisé sous le nom de Diflucan, est un antifongique appartenant à la classe des triazolés. Son action repose sur l’inhibition de la 14α-déméthylase dépendante du cytochrome P450, empêchant la conversion du lanostérol en ergostérol, composant essentiel de la membrane fongique. Cette inhibition fragilise la membrane et conduit à la mort cellulaire. La biodisponibilité du fluconazole est élevée (90 %), avec une pénétration efficace dans le liquide céphalorachidien, ce qui justifie son utilisation dans les méningites cryptococciques. Sa demi-vie longue permet des administrations espacées. Les données cliniques soulignent son rôle dans la prise en charge des candidoses systémiques, des candidémies et des infections opportunistes chez les sujets immunodéprimés. Les références thérapeutiques indiquent que diflucan prix est intégré dans de nombreux protocoles, tout en rappelant la surveillance nécessaire des enzymes hépatiques et les interactions avec les substrats du CYP3A4 et du CYP2C9.

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  • Dat Boy Lloyd - Love'em!

    Nice fit in my 2011 Super Crew XLT. Collects dirt and water as promised with no issues. Easy to remove and spray off when needed and haven't had any problems so far. Good buy!

  • D. S. - 50 Lbs 3 Inch Chlorine Tablets

    This is the biggest bucket of chlorine I could find. Each tablet individually wrapped and then within a plastic bag. The best price I could find and with free shipping it was a no brainer. I would of ordered more but I only have room for the one bucket. I hope it is still being sold when I need it again.