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Le fluconazole, commercialisé sous le nom de Diflucan, est un antifongique appartenant à la classe des triazolés. Son action repose sur l’inhibition de la 14α-déméthylase dépendante du cytochrome P450, empêchant la conversion du lanostérol en ergostérol, composant essentiel de la membrane fongique. Cette inhibition fragilise la membrane et conduit à la mort cellulaire. La biodisponibilité du fluconazole est élevée (90 %), avec une pénétration efficace dans le liquide céphalorachidien, ce qui justifie son utilisation dans les méningites cryptococciques. Sa demi-vie longue permet des administrations espacées. Les données cliniques soulignent son rôle dans la prise en charge des candidoses systémiques, des candidémies et des infections opportunistes chez les sujets immunodéprimés. Les références thérapeutiques indiquent que diflucan prix est intégré dans de nombreux protocoles, tout en rappelant la surveillance nécessaire des enzymes hépatiques et les interactions avec les substrats du CYP3A4 et du CYP2C9.
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Avast used to be very good and came highly recommended. In fact I used avast for near 7 or 8 years. Now with all the ads and popups it is just rather annoying anymore. I understand what they are trying to do to make money, but enough already with the popups that just will not go away until "X"d out.
I had the previous model (C305) which is now discontinued. It had grips that could be held. The grips on both sides of the knife for this model are too thin. The blade is good. Like the older model, this keeps an edge and is easy to sharpen. These knives are difficult to find at stores, anymore. I wish that Leatherman would re-make the C305 model along with this one. Sometimes older is better.
It fit as described and comes with other sizes of o-rings to adjust the fit. I like the color and the graphic and letters design on the top of it.