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Le fluconazole, commercialisé sous le nom de Diflucan, est un antifongique appartenant à la classe des triazolés. Son action repose sur l’inhibition de la 14α-déméthylase dépendante du cytochrome P450, empêchant la conversion du lanostérol en ergostérol, composant essentiel de la membrane fongique. Cette inhibition fragilise la membrane et conduit à la mort cellulaire. La biodisponibilité du fluconazole est élevée (90 %), avec une pénétration efficace dans le liquide céphalorachidien, ce qui justifie son utilisation dans les méningites cryptococciques. Sa demi-vie longue permet des administrations espacées. Les données cliniques soulignent son rôle dans la prise en charge des candidoses systémiques, des candidémies et des infections opportunistes chez les sujets immunodéprimés. Les références thérapeutiques indiquent que diflucan prix est intégré dans de nombreux protocoles, tout en rappelant la surveillance nécessaire des enzymes hépatiques et les interactions avec les substrats du CYP3A4 et du CYP2C9.
GATTEX® (teduglutide [rDNA origin]) for Injection - GATTEX® is a prescription medicine for adults with Short Bowel Syndrome who need additional nutrition or fluids from IV feeding. See Serious Side Effects.
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Murray observes that our society is incredibly polarized through cognitive sorting. At the top individuals with more human capital are increasingly able to develop their full potential within an intensive knowledge based marketplace. As a result, the median family income at the 95th percentile and above has risen rapidly since 1960. Meanwhile, the individuals with lesser potential are stagnating. Blue collar unionized manufacturing jobs are gone. Without a college degree, these individuals standard of living is static. Consequently, at the 25th percentile income has remained flat since 1960 (Fig. 2.1 page 49).