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Le fluconazole, commercialisé sous le nom de Diflucan, est un antifongique appartenant à la classe des triazolés. Son action repose sur l’inhibition de la 14α-déméthylase dépendante du cytochrome P450, empêchant la conversion du lanostérol en ergostérol, composant essentiel de la membrane fongique. Cette inhibition fragilise la membrane et conduit à la mort cellulaire. La biodisponibilité du fluconazole est élevée (90 %), avec une pénétration efficace dans le liquide céphalorachidien, ce qui justifie son utilisation dans les méningites cryptococciques. Sa demi-vie longue permet des administrations espacées. Les données cliniques soulignent son rôle dans la prise en charge des candidoses systémiques, des candidémies et des infections opportunistes chez les sujets immunodéprimés. Les références thérapeutiques indiquent que diflucan prix est intégré dans de nombreux protocoles, tout en rappelant la surveillance nécessaire des enzymes hépatiques et les interactions avec les substrats du CYP3A4 et du CYP2C9.

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  • Cardinal Phil - a Midnight Rendevous with Sir Paul's songs

    A fabulous collection of covers of songs by Paul McCartney done lovingly done by John Pizzarelli in a modern Smooth Jazz feel ; with each song arraigned individually with care. The previous recorded rock songs like "Coming Up" are fabulously redone One song I never heard(or I do not remember ) is the song "Some People never know" . Truly a fun CD to listen to . The song "A Wonderful Christmas Time" reminded me of my favorite Christmas Album called "Joy to the World " By the group "Pink Martini"

  • Cville MTBer - So far so good. The adjustable strap is very convenient and accessible ...

    So far so good. The adjustable strap is very convenient and accessible from the front of the bag. I am able to fit 2 computers in the computer sleeve. A 13 in ThinkPad and a surface 4. The bag is very large so when I have it across my body, it is very large. Great personal bag for check on though.

  • killerbee - Great Stroller for the Money

    I like this stroller and it's a great buy for the money. It's great for around town use like shopping and walks to the park, but I don't recommend it for any type of unpaved trail or off roading since the tires are not suitable for that kind of terrain. (I knew this before I bought it.)

  • retrdpsych - Great product for my needs

    Bought this on Amazon because OFF! no longer handles this product. I have had chemotherapy 3 times and a stem cell transplant which caused my skin to be very intolerant of other repellants especially those with Deet. This product does the job and does not irritate my skin. I bought the cream as well as the liquid spray. Both work equally well.

  • Amazon Customer - Didn't Like them at all

    Didn't Like them at all ; after two days of using it the volume is very low and it comes in and out... And people I talk to can't hear me :(

  • Anne S. - It has a great weight to it that I fell in love with ...

    This is the same razor that the Dollar Shave Club uses for its executive package - except much cheaper! It has a great weight to it that I fell in love with while borrowing my friend's razor. Because of that weight, the razor does the work for me when I use it to shave my legs. I'm not married to the 6 Plus razor heads, but luckily, the regular Pace 6 blades work with this handle as well, which I plan on using in the future (I don't need the detail blade for my legs).

  • Ladysmith - It really does help with the pain of a UTI or cystitis

    This really does help, it is such a relief. I could care less about what color my urine is. This helps not only with UTIs along with antibiotics, but also "honeymoon cystitis" - plus some Vagincaine "down there." The price on Amazon is very good and the shipping fast.