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Le fluconazole, commercialisé sous le nom de Diflucan, est un antifongique appartenant à la classe des triazolés. Son action repose sur l’inhibition de la 14α-déméthylase dépendante du cytochrome P450, empêchant la conversion du lanostérol en ergostérol, composant essentiel de la membrane fongique. Cette inhibition fragilise la membrane et conduit à la mort cellulaire. La biodisponibilité du fluconazole est élevée (90 %), avec une pénétration efficace dans le liquide céphalorachidien, ce qui justifie son utilisation dans les méningites cryptococciques. Sa demi-vie longue permet des administrations espacées. Les données cliniques soulignent son rôle dans la prise en charge des candidoses systémiques, des candidémies et des infections opportunistes chez les sujets immunodéprimés. Les références thérapeutiques indiquent que diflucan prix est intégré dans de nombreux protocoles, tout en rappelant la surveillance nécessaire des enzymes hépatiques et les interactions avec les substrats du CYP3A4 et du CYP2C9.

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  • Audra Blais - Has a kick!

    These little sticks are really neat. I was kind of thinking this sounded to good to be true and were a bit gimmicky. However I found these do indeed work and add an extra boost to pretty much any drink. They do have a slight flavor to them that can be a bit bitter. However you would most likely only notice it in lighter tasting drinks such as tea or water. They blend into your drink and only leave a small about of stuff on the bottom of the cup. This is a great thing to use to avoid unwanted calories but get your boost in.

  • D. Connelly - Kind of disappointed

    My current backpack of choice is a High Sierra single strap backpack. I got this one since I thought it would be the same as my other backpack, but have two straps. There are a couple things that sadly are not the same. The main compartment doesn't have a padded divider. Since I use my backpack mostly to carry around my laptop, a padded divider would have been a HUGE plus. The second thing is that the compartment meant for your iPod (or other mp3 player of your choice) is the same plasticy fabric that lines rest of the backpack. In my single strap High Sierra, it had soft fabric for that compartment which definitely prevented scratching. The yolk at the top between the two straps is uncomfortable. I can feel it pressing against my back. Maybe I just haven't adjusted it correctly yet. Those things aside, it still has the same high quality construction and has plenty of room. Maybe once I break it in a bit more I'll be happier with it.

  • GapperJay - Works well but not much of a difference in a ...

    Works well but not much of a difference in a 4.5 to 4.6 f ratio dobs. My type I appears to be sufficient.

  • gmoney - the stuff works!

    This is the only brand on the market known to work to me. I have used it many times all with success. You can't just drink the drink and hope for the best, you will need to do a lil research and follow all the instuctions for it to work. Would like to shake the persons hand who makes this stuff!

  • Amazon Customer - I am taking this suplemento because my job regueros me ...

    I am taking this suplemento because my job regueros me to get up early and I need to reforestation my emmune system