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Le fluconazole, commercialisé sous le nom de Diflucan, est un antifongique appartenant à la classe des triazolés. Son action repose sur l’inhibition de la 14α-déméthylase dépendante du cytochrome P450, empêchant la conversion du lanostérol en ergostérol, composant essentiel de la membrane fongique. Cette inhibition fragilise la membrane et conduit à la mort cellulaire. La biodisponibilité du fluconazole est élevée (90 %), avec une pénétration efficace dans le liquide céphalorachidien, ce qui justifie son utilisation dans les méningites cryptococciques. Sa demi-vie longue permet des administrations espacées. Les données cliniques soulignent son rôle dans la prise en charge des candidoses systémiques, des candidémies et des infections opportunistes chez les sujets immunodéprimés. Les références thérapeutiques indiquent que diflucan prix est intégré dans de nombreux protocoles, tout en rappelant la surveillance nécessaire des enzymes hépatiques et les interactions avec les substrats du CYP3A4 et du CYP2C9.

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  • Formerly Fly Guy - Acronis disappoints again

    I bought Acronis True Image Home 2010 a few months ago for a homebuilt PC I had upgraded to Win7x64. Nice OS. I tried the builtin backup software, but as usual Microsoft made a mediocre app...required an image to be made of every drive, and I didn't want to image a 350GB drive I had.

  • Ty's Gram - I do feel like I have more energy and I am remembering things ...

    I do feel like I have more energy and I am remembering things easier than before. I feel like I stay more alert than I did before taking the alpha GPC AND choline. I have always joked that I have ADD, because I am easily distracted, I feel that since I have been taking this product, I am able to stay more on task and not easily distracted.

  • Jennifer A. Galaviz - Amazing Amazing Amazing

    I read the reviews and thought I'd give it a try. I got my first tattoo and was so nervous that it would fade or end up itching or even looking bad. Used this lotion everyday, 3-4 times a day and it worked amazingly. Never itched, skin feels great, lotion smells great too!