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Le fluconazole, commercialisé sous le nom de Diflucan, est un antifongique appartenant à la classe des triazolés. Son action repose sur l’inhibition de la 14α-déméthylase dépendante du cytochrome P450, empêchant la conversion du lanostérol en ergostérol, composant essentiel de la membrane fongique. Cette inhibition fragilise la membrane et conduit à la mort cellulaire. La biodisponibilité du fluconazole est élevée (90 %), avec une pénétration efficace dans le liquide céphalorachidien, ce qui justifie son utilisation dans les méningites cryptococciques. Sa demi-vie longue permet des administrations espacées. Les données cliniques soulignent son rôle dans la prise en charge des candidoses systémiques, des candidémies et des infections opportunistes chez les sujets immunodéprimés. Les références thérapeutiques indiquent que diflucan prix est intégré dans de nombreux protocoles, tout en rappelant la surveillance nécessaire des enzymes hépatiques et les interactions avec les substrats du CYP3A4 et du CYP2C9.

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  • Ryker - It works but use caution

    I was super excited when I saw this product bc I tend to use NyQuil as a sleep aid but hate all the extra medicine I'm taking. So I tried this for the first time last night and took the recommended dose. I fell right to sleep but woke up 5 hours later naked, sprawled at the end of my side of the bed, and with no covers on. I have no idea how any of this happened. My husband is a deep sleeper and said he didn't hear anything. I guess I must have been sleepwalking and striping. From now on I will try half a dose and see how it goes. I recommend that if its your first time take half just in case.

  • Amazon Customer - These salespeople are so good and so well trained

    These salespeople are so good and so well trained. I saw it coming, and opted to see what they had to say. Finially, said to them, you've been scammed, my intention was to see how they handled my rejection at not purchasing the product. OMG...... they were so so good, and so well trained at how to answer. Gold Elements should be ashamed of themselves!!!

  • George Takei - Iran, Iran so far away

    Brad and I figured it would be poetic justice to tuck one of these babies, along with a DVD of hard core gay porn, inside a gift basket sent to our favorite Iranian madman, ex-President Mahmoud Ahmadinejad, during his last rant-filled visit to the UN. Just a small token of our esteem and thanks, you understand, for torturing and hanging those two gay teens.

  • Amy McKinney - They work!

    they definitely helped curb appetite and helped me loose weight. I used them in conjunction with a B12 supplement, and a VERY VERY clean eating plan. I've lost 25 pounds in about 3 weeks from all things combined. It HELPS you along the way! YOU have to be in control of what you do, but this can give you a little extra edge.

  • Clara S. - Clever, Spoooooky, and Honest.

    I loved this documentary! It was so funny, and probably the most real and honest exploration into the world of ghosts I have encountered. Not only was it nice to have both skeptics and believers together, but the discussions around their experiences were authentic and grounded. It is definitely a refreshing look at the paranormal. Highly recommended.