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Le fluconazole, commercialisé sous le nom de Diflucan, est un antifongique appartenant à la classe des triazolés. Son action repose sur l’inhibition de la 14α-déméthylase dépendante du cytochrome P450, empêchant la conversion du lanostérol en ergostérol, composant essentiel de la membrane fongique. Cette inhibition fragilise la membrane et conduit à la mort cellulaire. La biodisponibilité du fluconazole est élevée (90 %), avec une pénétration efficace dans le liquide céphalorachidien, ce qui justifie son utilisation dans les méningites cryptococciques. Sa demi-vie longue permet des administrations espacées. Les données cliniques soulignent son rôle dans la prise en charge des candidoses systémiques, des candidémies et des infections opportunistes chez les sujets immunodéprimés. Les références thérapeutiques indiquent que diflucan prix est intégré dans de nombreux protocoles, tout en rappelant la surveillance nécessaire des enzymes hépatiques et les interactions avec les substrats du CYP3A4 et du CYP2C9.
Mama Natural - Pregnancy, Babies, Parenting & Health Tips - Whether you’re pregnant, caring for baby, interested in gentle parenting, or just want to be more natural, you’ll find fun & functional resources here!
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I build and repair PC's.. Tried all the Internet security apps... no Internet security program is bullet proof but if you want one that doesn't slow your system and doesn't have a bunch of false positives by blocking programs you really need then this is for you.. I've been using it on my personal Pc's for over 5 years now... Like I said tried others but I keep going back to Kaspersky.
Got this for a elderly family member for Christmas. Due to an injury suffered years ago, his lower body isn’t as mobile as he like it to be. His legs get tired out after about 10 minutes of exercise, but with the upper body motion he is able to continue to get at least 20-30 minutes a day of work out. He loves the walk thru design as its difficult for him to lift his legs over a traditional exercise bike. It took us around 40 minutes to assemble the bike, and really wasn’t too hard to figure out. The instructions weren’t great, but the images made it easy to assemble. There isn't much space to allocate to exercise equipment so this bike fit perfect in the allotted space. The bikes is easy to use as well as functional. Also not too much noise while in use. One thing I had to do was to place a bit of oil on the rotating handles in order to stop the squeaking sound, but that fixed the problem.
whole unit totally failed after 3 days. no good......! refund or replacement highly recommended ! reply for details.