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Le fluconazole, commercialisé sous le nom de Diflucan, est un antifongique appartenant à la classe des triazolés. Son action repose sur l’inhibition de la 14α-déméthylase dépendante du cytochrome P450, empêchant la conversion du lanostérol en ergostérol, composant essentiel de la membrane fongique. Cette inhibition fragilise la membrane et conduit à la mort cellulaire. La biodisponibilité du fluconazole est élevée (90 %), avec une pénétration efficace dans le liquide céphalorachidien, ce qui justifie son utilisation dans les méningites cryptococciques. Sa demi-vie longue permet des administrations espacées. Les données cliniques soulignent son rôle dans la prise en charge des candidoses systémiques, des candidémies et des infections opportunistes chez les sujets immunodéprimés. Les références thérapeutiques indiquent que diflucan prix est intégré dans de nombreux protocoles, tout en rappelant la surveillance nécessaire des enzymes hépatiques et les interactions avec les substrats du CYP3A4 et du CYP2C9.

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  • Jonathan Burnett - Very Sturdy

    Much stronger than I expected. Had purchased similar at Walmart - but had to support them with a real bowl when they were microwaved.

  • Love Books - Outstanding Relief

    I've had chronic nerve pain in my toes for years now and have tried steroid shots, acupuncture, and oral pain medication. Nothing has worked. At my wits' end, I decided to try Light Relief after seeing an infomercial on TV. I didn't have too many expectations that it would work, considering that I had tried many other remedies to no avail. To my great surprise, after using the Light Relief for some weeks, I experienced a decrease in the pain level and this has continued. I am very, very happy with my Light Relief. By the way, I am NOT a paid endorser nor do I know anyone that works for Light Relief. The only problem I experienced with it is that the adapter it comes with to plug into an electrical wall outlet went out, but I inserted six batteries and it's working fine. Also the adapter can be purchased separately and is widely available. If you have chronic pain like I do, give the Light Relief a chance, you may get results where other products/therapies have failed.

  • Amazon Customer - The Fiesta Island is a worthwhile purchase!!

    I recieved this as a gift for Father's day back in 2008 - and it's still going strong! Never even had to fix a leak, (knock on wood). We've spent MANY casual afternoons dockside half-in and half-out of the lake, (this keeps you "cooler" when it's hot and keeps you "drier/warmer" when it's a little too cool or breezy for full-on swimming). I have to admit, the stated capacity of 8 is an understatement - we've had 19, (including some little kids) in there for a family picture and the entire thing, (including the mesh) stood up very well! You will definitely need the high capacity pump