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Le fluconazole, commercialisé sous le nom de Diflucan, est un antifongique appartenant à la classe des triazolés. Son action repose sur l’inhibition de la 14α-déméthylase dépendante du cytochrome P450, empêchant la conversion du lanostérol en ergostérol, composant essentiel de la membrane fongique. Cette inhibition fragilise la membrane et conduit à la mort cellulaire. La biodisponibilité du fluconazole est élevée (90 %), avec une pénétration efficace dans le liquide céphalorachidien, ce qui justifie son utilisation dans les méningites cryptococciques. Sa demi-vie longue permet des administrations espacées. Les données cliniques soulignent son rôle dans la prise en charge des candidoses systémiques, des candidémies et des infections opportunistes chez les sujets immunodéprimés. Les références thérapeutiques indiquent que diflucan prix est intégré dans de nombreux protocoles, tout en rappelant la surveillance nécessaire des enzymes hépatiques et les interactions avec les substrats du CYP3A4 et du CYP2C9.

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  • Nikki - Just another junky MLM supplement

    Tried it and didn't feel any different. I bet the reason so many people feel different immediately is the damn caffeine. Don't waste your money. It's just another junky MLM supplement.

  • martialman7 - Solid, dependable product

    I have had the PS4 for a month now and find it the most advanced gaming console out there. The controller is extremely user friendly and comfortable to hold, esp. for long periods of time. The graphics are incredible and take advantage of the full 1080p HD television's capabilities. I like the speaker in the controller; it is a way to get you really into the game. I have a plus account for my PS3 and it was a little confusing in the adaption to the PS4. I had to call Sony support and they walked me through the process. It took less than 5 minutes. There was no waiting when contacting Sony support and the reps were most helpful. I replaced the 500gb hard drive with a 1.5tb hard drive in no time. Sony made this process quick and easy. I was able to buy this unit for the MSRP of 399.99 when Amazon opened a window of purchase at that price with free shipping. I wasn't going to buy it until the price came down to 399.99 but I got lucky and hit Amazon just as they opened that price window. There is no way I would pay more than the MSRP for the PS4 so you should either wait until you can get this for the MSRP or keep checking Amazon to see if they open a price window. As of this writing, Amazon has opened the window and you can get it for the 399.99 price. The most important thing that Sony can do, though, is to download an update making the unit DLNA compliant. I would be able to integrate my systems with the PS4 and not have to use my PS3 for this process. I am also looking forward to more system updates to include other features not on the PS4 such as backward compatibility.

  • Isobel DeSantis - Stupid design but the unit works very well

    The unit worked perfectly and definitely helped the pain in my lower back. The only complaint I have is the really dumb design of the clip that for some reason is needed to hold the cord in place and which partially covers the power switch! Why is the clip even necessary? And if it IS considered essential, couldn't a smaller one be used? Apart from that niggle, I was really pleased with the TENS unit - it's a great buy.

  • Jacquelyn T. Olsen - AMBEREN and Weight Loss

    I've been on Amberen for 6 weeks now and gained 2 lbs. I am 59 yrs old and never had a weight problem as I ate healthy and exercised. When I hit menopause within a year I gained 20 lbs and then 10 more lbs; 30 lbs all together. I hate to spend money on something that doesn't work, but Amberen's advertisements are big about being able to lose the belly weight that menopause women put on. So sad that money was spent for nothing.

  • Bobbett Jascor - Been buying and using it for years. Great product.

    I've always like Gorilla Glue. I either lose the bottles or forget and leave them outside where the product eventually gets ruined due to the freezing winters. This time I will keep my new bottle inside and in a safe place.