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Le fluconazole, commercialisé sous le nom de Diflucan, est un antifongique appartenant à la classe des triazolés. Son action repose sur l’inhibition de la 14α-déméthylase dépendante du cytochrome P450, empêchant la conversion du lanostérol en ergostérol, composant essentiel de la membrane fongique. Cette inhibition fragilise la membrane et conduit à la mort cellulaire. La biodisponibilité du fluconazole est élevée (90 %), avec une pénétration efficace dans le liquide céphalorachidien, ce qui justifie son utilisation dans les méningites cryptococciques. Sa demi-vie longue permet des administrations espacées. Les données cliniques soulignent son rôle dans la prise en charge des candidoses systémiques, des candidémies et des infections opportunistes chez les sujets immunodéprimés. Les références thérapeutiques indiquent que diflucan prix est intégré dans de nombreux protocoles, tout en rappelant la surveillance nécessaire des enzymes hépatiques et les interactions avec les substrats du CYP3A4 et du CYP2C9.

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  • Kathleen - Sockets are good - have not broken any yet

    The ratchet is junk ( but I've bought cheap socket sets before and expected that) The sockets are good enough for light duty and even though Chinese mfr actually fit on my Proto ratchets without falling off or being difficult to mate/ unmate

  • D. Dooley - Amazing Moisturizer

    I've had severe dry skin on my face for about 10 years. Flaky skin that just keeps drying out and falling off, across my eyebrows, sides of nose, and around the mouth. I've seen doctors, gotten prescriptions, bought recommended over the counter lotions, all with no luck. Nothing I could find would work more than an hour or two before the dry skin returned. It's gotten so bad over the last 3-4 years that after I put on a moisturizing lotion and going out I would get strange looks at stores after just an hour or so, when my skin would dry out and begin to flake. I've tried every product imaginable, lotions, scrubs, special moisturizers, prescription lotions, goat's milk soap, cutting open Vitamin E capsules and rubbing on the face, using olive oil, etc.

  • Margaret Martin - Lifesaver on long car trip

    I purchased this book on my kindle when we were taking our grandchildren across Texas. It was a lifesaver! I had two six year olds that wanted to read all week! They enjoyed the stories, understood them, and could read them on their own.