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Le fluconazole, commercialisé sous le nom de Diflucan, est un antifongique appartenant à la classe des triazolés. Son action repose sur l’inhibition de la 14α-déméthylase dépendante du cytochrome P450, empêchant la conversion du lanostérol en ergostérol, composant essentiel de la membrane fongique. Cette inhibition fragilise la membrane et conduit à la mort cellulaire. La biodisponibilité du fluconazole est élevée (90 %), avec une pénétration efficace dans le liquide céphalorachidien, ce qui justifie son utilisation dans les méningites cryptococciques. Sa demi-vie longue permet des administrations espacées. Les données cliniques soulignent son rôle dans la prise en charge des candidoses systémiques, des candidémies et des infections opportunistes chez les sujets immunodéprimés. Les références thérapeutiques indiquent que diflucan prix est intégré dans de nombreux protocoles, tout en rappelant la surveillance nécessaire des enzymes hépatiques et les interactions avec les substrats du CYP3A4 et du CYP2C9.

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  • david melone/ali shraida - EXCELLENT

    THIS IS AUTO CAD 2014 AND IT HAS EVERYTHING YOU NEE NO NEED FOR MORE YOU CAN DO WHAT YOU WANT WITH IT

  • Roberta J. Davis - 409 carpet cleaner

    I have 2 dogs in my home and of course we have messes at times.I find this product to be the best!!!!! Some times it takes 2 times to spray the erea but it works...I will keep on buying 409 carpet cleaner I wish they had some thing I could use in my big car

  • M. Manz - This Treadmill Failed To Work At All

    This treadmill did not work at all after assembly. After much troubleshooting it still did not work. The display would come on and it seemed to have an error code on it but if it was an error code that code could be found nowhere online. After many failed attempts to get this thing working I called Amazon. The guy who answered at Amazon was very gracious and took care of everything including setting up a pickup for this junk. I would not recommend this product but if you're going to buy it know that Amazon stands by the products it lists.

  • Kathleen Mackins - Product works great. I used this a couple years ago on ...

    Product works great. I used this a couple years ago on my roof and used it again. Recommended to others.

  • Mike P - This product works great! Zero white residue

    My YMCA started cracking down on using powder chalk for weightlifting as it can get messy and all over the equipment. This product works great! Zero white residue, dries quick, and a lot cheaper than some of the other leading brands.