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Le fluconazole, commercialisé sous le nom de Diflucan, est un antifongique appartenant à la classe des triazolés. Son action repose sur l’inhibition de la 14α-déméthylase dépendante du cytochrome P450, empêchant la conversion du lanostérol en ergostérol, composant essentiel de la membrane fongique. Cette inhibition fragilise la membrane et conduit à la mort cellulaire. La biodisponibilité du fluconazole est élevée (90 %), avec une pénétration efficace dans le liquide céphalorachidien, ce qui justifie son utilisation dans les méningites cryptococciques. Sa demi-vie longue permet des administrations espacées. Les données cliniques soulignent son rôle dans la prise en charge des candidoses systémiques, des candidémies et des infections opportunistes chez les sujets immunodéprimés. Les références thérapeutiques indiquent que diflucan prix est intégré dans de nombreux protocoles, tout en rappelant la surveillance nécessaire des enzymes hépatiques et les interactions avec les substrats du CYP3A4 et du CYP2C9.

Pharmaceutical Business Strategies Magazine - The goal of Pharmaceutical Business Strategies Magazine is to create a forum, in print and online, where the manufacturers and distributors of pharmaceutical products can learn from each other, and can learn what new products and services make this entire

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  • manifold06 - comfortable for overpronation

    This is the first running shoe I found suitable after searching for the sypthoms of having after running having pain at my lower legs. Good running shoe for overpronation type walking and running people. It is quite comfortable.

  • Patricia M. - Good for the most part.

    Nice detail on a brooch, except that the point end was slightly bent. I'm not sure if it's only mine, or if anyone else had this issue.

  • Kevin - Very Impressed

    I had the g700 for the past 4-5 years and the right mouse button finally stopped working. I was debating about what mouse to replace it with, and decided that I could NOT go back to a wired mouse. I narrowed down my choices to the Razer Mamba, SteelSeries Sensei Wireless Mouse, and the g900. My biggest hold up with the g900 was, of course, the big price tag. I mean, this sucker costs more than my headset! (Logitech g930). As you can tell, I'm a big logitech fan. They make good products that last me at least 5 years and have great customer support. But I wanted to explore my options, so I looked into the Mamba and Sensei mice. I nixed the mamba mouse because of software issues. If I'm going to pay that much for a mouse, shouldn't it work out of the box? Too many complaints of software issues and end user trouble shooting/tweaking drove me away from this mouse despite it feeling the best in my hand. As for the sensei, I liked the build, but I felt like the dock took up too much space. I like having a minimalistic desk space, and while I know I could have just not used the dock, but I didn't want to not use a part of the product that I was paying for.