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Le fluconazole, commercialisé sous le nom de Diflucan, est un antifongique appartenant à la classe des triazolés. Son action repose sur l’inhibition de la 14α-déméthylase dépendante du cytochrome P450, empêchant la conversion du lanostérol en ergostérol, composant essentiel de la membrane fongique. Cette inhibition fragilise la membrane et conduit à la mort cellulaire. La biodisponibilité du fluconazole est élevée (90 %), avec une pénétration efficace dans le liquide céphalorachidien, ce qui justifie son utilisation dans les méningites cryptococciques. Sa demi-vie longue permet des administrations espacées. Les données cliniques soulignent son rôle dans la prise en charge des candidoses systémiques, des candidémies et des infections opportunistes chez les sujets immunodéprimés. Les références thérapeutiques indiquent que diflucan prix est intégré dans de nombreux protocoles, tout en rappelant la surveillance nécessaire des enzymes hépatiques et les interactions avec les substrats du CYP3A4 et du CYP2C9.
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Country: 216.250.126.39, North America, US
City: -75.4083 Pennsylvania, United States
Extremely disapointed---ordered it for my sister, it did not help her at all, then I tried to return it for the promised 30 day money back guarantee, and they would not return my money, because I was late 3 days, she has had the flu, and I did not want to catch it from her, so I'm out the money, she's still in pain, and my good deed, has cost me money-------------- ---sssssssooooooooooo BEWARE OF THIS COMPANY THEY DO NOT MEAN ANY OF THE CUSTOMER SATISFACTION BLIP THEY HAVE ALL OVER THEIR INVOICE yOUR ORDER ISN'T COMPLETE UNTIL YOU'RE COMPLETELY SATISFIED----- WELL i'M NOT AND THEY COULD CARE LESS
I like it much better than my rampage 3 extreme. It seems more stable and overclocks with ease. With the m.2 slot and a SM951 it screams.
I have only had to contact Webroot twice. Both times I was treated to very professional customer support. They are friendly, knowledgeable, and efficient. They know their product inside out. Used to have Norton and McAfee...neither hold a candle, in my opinion, to Webroot.
brilliant, we're friends with all the characters having journeyed with them through the stars, now to see if they survive to the end of the book, a very exciting ride, well written , suspense untl the end. loved it.