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Le fluconazole, commercialisé sous le nom de Diflucan, est un antifongique appartenant à la classe des triazolés. Son action repose sur l’inhibition de la 14α-déméthylase dépendante du cytochrome P450, empêchant la conversion du lanostérol en ergostérol, composant essentiel de la membrane fongique. Cette inhibition fragilise la membrane et conduit à la mort cellulaire. La biodisponibilité du fluconazole est élevée (90 %), avec une pénétration efficace dans le liquide céphalorachidien, ce qui justifie son utilisation dans les méningites cryptococciques. Sa demi-vie longue permet des administrations espacées. Les données cliniques soulignent son rôle dans la prise en charge des candidoses systémiques, des candidémies et des infections opportunistes chez les sujets immunodéprimés. Les références thérapeutiques indiquent que diflucan prix est intégré dans de nombreux protocoles, tout en rappelant la surveillance nécessaire des enzymes hépatiques et les interactions avec les substrats du CYP3A4 et du CYP2C9.

Primary Health Tasmania - Primary Health Tasmania is a non-government, not-for-profit primary health care organisation working to help coordinate and connect primary health care services for local communities. We are funded to manage a range of programs and services in areas including after hours care, aged care, mental health, Aboriginal health, refugee health, chronic conditions, health promotion and eHealth.

http://www.primaryhealthtas.com.au/for-health-professionals For health professionals | Primary Health Tasmania - Primary Health Tasmania is responsible for improving the efficiency, effectiveness and coordination of primary care. We support general practice – as the cornerstone of the health care system – and other community-based providers to deliver the best possible care for Tasmanians, particularly those most at risk of poor health outcomes.

http://www.primaryhealthtas.com.au/commissioning Commissioning | Primary Health Tasmania - Commissioning primary health services for better health outcomes is a core activity for Primary Health Tasmania. Service providers can keep up-to-date with our latest tenders by registering on our eTender portal. Indicative timelines for tenders expected to be released between now and 30 June 2017 are listed below. Note that the quarters relate to calendar years, not financial years. This information is subject to change.

http://www.primaryhealthtas.com.au/careers Careers | Primary Health Tasmania - Are you looking for a role where you can make a real difference to the health of Tasmanians? Primary Health Tasmania may have the career opportunity you are looking for. Primary Health Tasmania is a non-government, not-for-profit organisation working to connect care and keep Tasmanians well and out of hospital. We are one of 31 primary health networks (PHNs) established nationally on 1 July 2015 as part of the Australian Government’s Primary Health Networks program.

http://www.primaryhealthtas.com.au/about-us/getting-involved Getting involved | Primary Health Tasmania - Health professionals, consumers and the broader community play a crucial role in supporting Primary Health Tasmania to connect care and keep Tasmanians well and out of hospital. There is a range of ways that we seek input from health professionals and the broader community. To register your interest in being kept up-to-date about opportunities for getting involved in Primary Health Tasmania, call us on 1300 653 169 or send us a message. Consultation

http://www.primaryhealthtas.com.au/about-us About us | Primary Health Tasmania - Primary Health Tasmania is a non-government, not-for-profit organisation working to connect care and keep Tasmanians well and out of hospital. The organisation is one of 31 similar bodies established around Australia on 1 July 2015 as part of the Primary Health Networks Programme – an Australian Government initiative. More information is available on the primary health networks website.

http://www.primaryhealthtas.com.au/feedback We welcome your feedback | Primary Health Tasmania - Primary Health Tasmania supports your right to make a compliment or complaint, express a concern or provide feedback about our work. We welcome feedback and complaints as part of our commitment to provide a high quality service. Tell us what we’re doing well. We appreciate hearing from you. If you have a concern, we also want to know about it.

http://www.primaryhealthtas.com.au/for-the-community For the community | Primary Health Tasmania - Primary Health Tasmania is a non-government, not-for-profit organisation working to connect care and keep Tasmanians well and out of hospital. Primary Health Tasmania is engaging with local communities to seek out the needs of Tasmanians and to identify solutions to those needs. For more information about this, go to our Getting involved page.

http://www.primaryhealthtas.com.au/programs-services/after-hours-care After hours care | Primary Health Tasmania - Primary health networks around Australia have a mandate to improve access to effective after hours services for local communities. Primary Health Tasmania has been working with health professionals and the community to ensure after hours services in this State are well-planned, coordinated, and appropriate to community needs. We are working on a range of measures aimed at improving after hours services for local communities. The after-hours period is: before 8:00am and after 6:00pm weekdays before 8:00am and after 12:00pm Saturdays all day Sundays and public holidays. How to find after hours medical services We have a dedicated website and a mobile app available to help you find after hours care. For more information, see our finding services page.

http://www.primaryhealthtas.com.au/about-us/our-publications Our publications | Primary Health Tasmania - View the latest publications from Primary Health Tasmania. Please contact us on 1300 653 169 or send us a message if you would like a hard copy of any of our publications. General Practice Matters newsletter General Practice Matters is a monthly newsletter giving GPs, practice nurses and other general practice staff practical information relevant to their work. View the General Practice Matters newsletters

http://www.primaryhealthtas.com.au/news/forum-improving-services-young-people-severe-mental-illness Forum on improving services for young people with severe mental illness | Primary Health Tasmania - Primary Health Tasmania is working with service providers and other stakeholders to develop innovative approaches to regional planning and integration of stepped care for young people with severe mental illness, in the lead-up to commissioning primary mental health care services. A forum for stakeholders working with young people with severe mental illness will be held in Hobart on Monday 31 October 2016.

http://www.primaryhealthtas.com.au/news/tender-opens-aboriginal-health-service-delivery Tender opens for Aboriginal health service delivery | Primary Health Tasmania - Primary Health Tasmania has opened a tender for the delivery of health services for Aboriginal and Torres Strait Islander peoples. Services will focus on improved management of chronic conditions through the Australian Government's Integrated Team Care (ITC) Activity program. The tender will close on 15 November, and service delivery will start in early 2017. Tender details are available by registering on Primary Health Tasmania's eTender portal.

http://www.primaryhealthtas.com.au/news/october-issue-of-general-practice-matters-newsletter-0 October issue of General Practice Matters newsletter | Primary Health Tasmania - The October issue of our General Practice Matters newsletter is available here In this issue:

http://www.primaryhealthtas.com.au/news/tasmania-named-health-care-home-trial-region Tasmania named as Health Care Home trial region | Primary Health Tasmania - Primary Health Tasmania welcomes the announcement by the Australian Government on 24 August that Tasmania will be included in the national Health Care Homes trial. “This is great news for Tasmania because we have high rates of chronic disease and an ageing population against a backdrop of significant socioeconomic disadvantage,” Phil Edmondson, CEO of Primary Health Tasmania (Tasmania’s Primary Health Network), said. The Australian Government describes the Health Care Homes model as a new way of funding care for people with chronic health conditions.

http://www.primaryhealthtas.com.au/news/primary-health-matters-magazine-issue-5 Primary Health Matters magazine: Issue 5 | Primary Health Tasmania - The latest issue of Tasmania’s primary health magazine, Primary Health Matters, is now available online here This magazine is produced by Primary Health Tasmania and aims to show how innovation in primary health and social care is making a difference and contributing to healthy Tasmanians, healthy communities, and a healthy system. It focuses on the work of Primary Health Tasmania’s member and partner organisations, as well as our own activities. In this issue:

http://www.primaryhealthtas.com.au/about-us/national-health-services-directory National Health Services Directory | Primary Health Tasmania - The National Health Services Directory (NHSD) is a free comprehensive national directory of health services. It enables you to access reliable, consistent and up to date information on services in your local area across the country. Search from a broad range of local health services including: general practices pharmacies specialists allied health services hospitals and emergency departments.

http://www.primaryhealthtas.com.au/programs-and-services/connecting-care/professionals/shared-transfer-of-care Shared transfer of care | Primary Health Tasmania - Transfer of care refers to the movement of people between locations, providers or different levels of care as their condition and care needs change. This movement is where adverse events and other negative impact on people and their carers can increase significantly. Poor quality transfer of care also places added stress on the Tasmanian health system.

http://www.primaryhealthtas.com.au/our-surveys Consultation | Primary Health Tasmania - Primary Health Tasmania is working to connect care and keep Tasmanians well and out of hospital. Listening to stakeholder and community feedback plays an important role in helping us to plan our activities and deliver services so they reflect the needs of local communities and the health professionals who care for them. We have no formal consultation open at present.

http://www.primaryhealthtas.com.au/programs-services/after-hours-care/finding-after-hours-medical-care Who do you call after hours? | Primary Health Tasmania - After hours medical care is for people whose health condition is urgent, is not a life-threatening medical emergency, but cannot wait for treatment until regular services are available. The after hours period is defined as: before 8am and after 6pm weekdays before 8am and after 12 noon Saturdays all day Sundays and public holidays. Your regular GP should always be your first point of call if you need urgent medical care and it's not a life-threatening medical emergency.

http://www.primaryhealthtas.com.au/terms-of-use Terms of use | Primary Health Tasmania - This web site is owned and operated by Primary Health Tasmania and will be referred to as "We", "our" and "us" in this Terms of Use policy. By using this site, you agree to the Terms of Use Policy of this web site ("the web site"), which is set out on this web site page.

http://www.primaryhealthtas.com.au/privacy-policy Privacy policy | Primary Health Tasmania - Protecting the privacy of your personal information In complying with the Privacy Amendment (Enhancing Privacy Protection) Act 2012, Primary Health Tasmania has developed an Information Privacy Policy that governs its handling of personal information. The Privacy Amendment (Enhancing Privacy Protection) Act 2012 defines personal information as "information or an opinion about an identified individual, or an individual who is reasonable identifiable".

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Bixby Reader - Many great stories; others not so good

Many stories are great, but I just couldn't get through a few and had to skip them. Perhaps I don't understand the bigger picture (?)

Customer - The new improve aftershave

Great nature aftershave product I love the way it make my face feel after a close shave. I never use this aftershave before from Pure Body Naturals but I'm so glad I purchase this after shave. It doesn't dry my handsome face out (lol) at all. I have used this daily because I shave every single day and I have no problem at all with dryness. Also the smell is not over powering but just right ( to me anyway). I received this after shave in a small box in a plastic with air bags to keep it from moving.