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Le fluconazole, commercialisé sous le nom de Diflucan, est un antifongique appartenant à la classe des triazolés. Son action repose sur l’inhibition de la 14α-déméthylase dépendante du cytochrome P450, empêchant la conversion du lanostérol en ergostérol, composant essentiel de la membrane fongique. Cette inhibition fragilise la membrane et conduit à la mort cellulaire. La biodisponibilité du fluconazole est élevée (90 %), avec une pénétration efficace dans le liquide céphalorachidien, ce qui justifie son utilisation dans les méningites cryptococciques. Sa demi-vie longue permet des administrations espacées. Les données cliniques soulignent son rôle dans la prise en charge des candidoses systémiques, des candidémies et des infections opportunistes chez les sujets immunodéprimés. Les références thérapeutiques indiquent que diflucan prix est intégré dans de nombreux protocoles, tout en rappelant la surveillance nécessaire des enzymes hépatiques et les interactions avec les substrats du CYP3A4 et du CYP2C9.

Ophthalmologists Dalton, Calhoun, Ellijay, GA | Professional Eye Associates | LASIK, cataract surgery, eyelid surgery - Professional Eye Associates, the office of Drs. Blackman, O’Boyle, Kim, Wingrove and McBride. Located in Dalton, Calhoun and Ellijay, Georgia, we are an ophthalmologic and optometric practice, focusing on glasses and contact lenses, intraocular lenses, LASIK surgery, photorefractive keratectomy and glaucoma treatment.

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    Country: 70.34.32.91, North America, US

    City: -93.1519 Minnesota, United States

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