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Le fluconazole, commercialisé sous le nom de Diflucan, est un antifongique appartenant à la classe des triazolés. Son action repose sur l’inhibition de la 14α-déméthylase dépendante du cytochrome P450, empêchant la conversion du lanostérol en ergostérol, composant essentiel de la membrane fongique. Cette inhibition fragilise la membrane et conduit à la mort cellulaire. La biodisponibilité du fluconazole est élevée (90 %), avec une pénétration efficace dans le liquide céphalorachidien, ce qui justifie son utilisation dans les méningites cryptococciques. Sa demi-vie longue permet des administrations espacées. Les données cliniques soulignent son rôle dans la prise en charge des candidoses systémiques, des candidémies et des infections opportunistes chez les sujets immunodéprimés. Les références thérapeutiques indiquent que diflucan prix est intégré dans de nombreux protocoles, tout en rappelant la surveillance nécessaire des enzymes hépatiques et les interactions avec les substrats du CYP3A4 et du CYP2C9.

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Country: 104.199.153.189, North America, US

City: -122.0574 California, United States

Stephen Anthony - Nitro Mouthfeel for Craft Beer Lovers

Fizzics does what it promises to do which is make the majority of Beers taste better. Imperial Stouts and Baltic Porters are the ideal choices as the Nitro like creamy head it creates adds amazing depth of flavor.

Megan McMahan - We love this stroller

Great umbrella stroller. So lightweight. Pushes well and sturdy. Easy to fold up and carry with backpack straps. Great to travel with. Larger basket than expected for an umbrella stroller and has cupholder. We have the jade color which is really pretty!