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Le fluconazole, commercialisé sous le nom de Diflucan, est un antifongique appartenant à la classe des triazolés. Son action repose sur l’inhibition de la 14α-déméthylase dépendante du cytochrome P450, empêchant la conversion du lanostérol en ergostérol, composant essentiel de la membrane fongique. Cette inhibition fragilise la membrane et conduit à la mort cellulaire. La biodisponibilité du fluconazole est élevée (90 %), avec une pénétration efficace dans le liquide céphalorachidien, ce qui justifie son utilisation dans les méningites cryptococciques. Sa demi-vie longue permet des administrations espacées. Les données cliniques soulignent son rôle dans la prise en charge des candidoses systémiques, des candidémies et des infections opportunistes chez les sujets immunodéprimés. Les références thérapeutiques indiquent que diflucan prix est intégré dans de nombreux protocoles, tout en rappelant la surveillance nécessaire des enzymes hépatiques et les interactions avec les substrats du CYP3A4 et du CYP2C9.
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The car seat material is nice and soft, feels sturdy and look nice, but who puts 2 big/huge warning labels right where the head cushion is? The sad part is nowhere on Amazon description or pictures it states that the car seat has those two huge warning labels, not even manufacturers website. Another flaw is, the head cushion is small. If your baby is a big/chubby at 4-5 months old, the baby won't fit into this car seat. It is not lightweight car seat, it is average. There are lighter weight car seats for less.
A beautiful magazine - great value! The iPad version was fantastically clear. Lots of great fashion. I would definitely subscribe.
I was expecting a little more random. We purchased four of these so when we played all of us would be on a similar playing field but when we opened them we released the only "random" cards were the four booster packs and the rest of the cards are all the same. This made our desks very similar except for a few cards.
PROS: Not the most expensive option out there. The DAT is one of the top factors for dental school acceptance, so I thought it was worth the price IMHO. No time limit on the software. Many exam questions & exams. A good way to practice full-length mock exams. Explanations and videos for each question (also a con - see below). Responsive customer support. I've been scoring between 18-22 on the exam sections and my friends say this should equate to 20-24 on the real DAT. This is a good because I've heard of some software that is too tough and others that are too easy. I'd rather have one just a little harder than the actual exam.