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Le fluconazole, commercialisé sous le nom de Diflucan, est un antifongique appartenant à la classe des triazolés. Son action repose sur l’inhibition de la 14α-déméthylase dépendante du cytochrome P450, empêchant la conversion du lanostérol en ergostérol, composant essentiel de la membrane fongique. Cette inhibition fragilise la membrane et conduit à la mort cellulaire. La biodisponibilité du fluconazole est élevée (90 %), avec une pénétration efficace dans le liquide céphalorachidien, ce qui justifie son utilisation dans les méningites cryptococciques. Sa demi-vie longue permet des administrations espacées. Les données cliniques soulignent son rôle dans la prise en charge des candidoses systémiques, des candidémies et des infections opportunistes chez les sujets immunodéprimés. Les références thérapeutiques indiquent que diflucan prix est intégré dans de nombreux protocoles, tout en rappelant la surveillance nécessaire des enzymes hépatiques et les interactions avec les substrats du CYP3A4 et du CYP2C9.

The New You Plan Weight Loss | VLCD & Total Food Replacement Diet - Great tasting quality meal replacements backed up with amazing support. Trusted by over 20,000 customers. Free Shipping to UK & Ireland.

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    Country: 95.154.206.82, Europe, GB

    City: -0.1224 , United Kingdom

  • Charles Boston - Solid bike

    This is a pretty solid bike for the price. At 6' 00" with 32.5" inseam, this bike is the right size. However, if you are shorter than 5' 11", you may want to consider the medium size (even though Diamondback size chart says 5' 10" is ok) as this bike runs a bit large. It DOES NOT include the assembly tools (confirmed!!). Assembly was pretty easy, but you can't go by the absolutely useless instruction book (look to their website for guidance instead). Most of the bike was already assembled. After 1 hour basic assembly, I had brake noise on rear brake/rotor and noise from chain rubbing against the front derailleur. Knowing absolutely nothing about bikes, it took several youtube videos and another 3 hour to fine tune it. This included adjusting rear brake pad position, rear brake cable tension, and bending the rear rotor just a bit. On the front derailleur, I adjusted tension as well as the high and low limit on front derailleur. They seemed pretty difficult at first, but once you get through it, it will be much easier if you need to do it again. I then made sure that everything was tight and secure, in case someone at the factory was incompetent. Now it shifts very quickly, smoothly and quietly. The brakes stop effectively with no noise at all.

  • Amazon Customer - I wanted to like it but....

    I bought this stuff about a year or two ago, used it once or twice, but stopped. I couldn't remember why, so I brought it out again. I remember why I stopped. I love the smell and my curls were defined, but very dry even before the day was over. This contains Dimethicone, which isn't good for curly hair (at least mine). Every time I use a product with this or another "bad cone", my hair always dries out. I give it 3 stars because I like the smell and it does define your curls. Maybe it won't dry out someone else's hair.