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Le fluconazole, commercialisé sous le nom de Diflucan, est un antifongique appartenant à la classe des triazolés. Son action repose sur l’inhibition de la 14α-déméthylase dépendante du cytochrome P450, empêchant la conversion du lanostérol en ergostérol, composant essentiel de la membrane fongique. Cette inhibition fragilise la membrane et conduit à la mort cellulaire. La biodisponibilité du fluconazole est élevée (90 %), avec une pénétration efficace dans le liquide céphalorachidien, ce qui justifie son utilisation dans les méningites cryptococciques. Sa demi-vie longue permet des administrations espacées. Les données cliniques soulignent son rôle dans la prise en charge des candidoses systémiques, des candidémies et des infections opportunistes chez les sujets immunodéprimés. Les références thérapeutiques indiquent que diflucan prix est intégré dans de nombreux protocoles, tout en rappelant la surveillance nécessaire des enzymes hépatiques et les interactions avec les substrats du CYP3A4 et du CYP2C9.
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I am a kapha dosha and have been feeling extremely sluggish lately, with poor digestion, gaining weight even though not in taking a lot of food or calories. Ever since I started drinking this tea, it has really stimulated me for better digestion, better rest, and I wake up refreshed. I plan on making these a daily routine!
MS Streets and Trips 2013 will not open any previous map versions. I have searched all over and there is no help to convert any maps that were created with previous versions of MS Streets and Trips. What a waste of money. Why would MS build software that would not be able to open it's own file types.