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Le fluconazole, commercialisé sous le nom de Diflucan, est un antifongique appartenant à la classe des triazolés. Son action repose sur l’inhibition de la 14α-déméthylase dépendante du cytochrome P450, empêchant la conversion du lanostérol en ergostérol, composant essentiel de la membrane fongique. Cette inhibition fragilise la membrane et conduit à la mort cellulaire. La biodisponibilité du fluconazole est élevée (90 %), avec une pénétration efficace dans le liquide céphalorachidien, ce qui justifie son utilisation dans les méningites cryptococciques. Sa demi-vie longue permet des administrations espacées. Les données cliniques soulignent son rôle dans la prise en charge des candidoses systémiques, des candidémies et des infections opportunistes chez les sujets immunodéprimés. Les références thérapeutiques indiquent que diflucan prix est intégré dans de nombreux protocoles, tout en rappelant la surveillance nécessaire des enzymes hépatiques et les interactions avec les substrats du CYP3A4 et du CYP2C9.

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  • Amazon Customer - not a miracle but still useful

    If you are looking for something that gives you energy this is good. I found I stuck to diet much more when on this. Of course you still need diet and exercise but this does keep u alert (caffeine) and does curb appetite a bit.

  • Lynne Merando - waste of money

    Wanted to get an extra charger for work, plugged it in and my phone constantly beeps every 2 seconds, thought maybe I could silence it and it would still work. does not work at all...waste of money!!! very disappointed! Normally I do not buy things like this online, this is why...stuck with 2 bad charger and out the money!! wish I could return!!!!!!

  • Raya Z. - Purchased 4-dog & 5-cat collars in October, put on ...

    Purchased 4-dog & 5-cat collars in October, put on pets November 1, within 3-day no sign of fleas, 30-days no sign of fleas, 60-days some fleas. 90-days total infestation on all animals.

  • Grandma Tamme - This supplement has helped me a great deal with this since taking it the last couple ...

    Sometimes I find it very hard to concentrate on one thing and I am bouncing around between several instead of efficiently working on task until the end. This supplement has helped me a great deal with this since taking it the last couple of days. I have started and completed several tasks without interruption or stopping to start another before the first one is done. I feel more alert and my short term memory even seems a little better. Thank you for a good product that shows good results by doing what it says it will do. Thank you for the discount I received when I ordered.

  • Dan W - Good value, sound, and they stay on the ears.

    I have had these now for 6 weeks wearing them daily. I wear these anytime I exercise (cycling, walking) or out and about for any reason. Another, cheaper brand is a backup (after 8 hours they do shut down) but those are not nearly as good in sound or staying in the ears as these. So I am likely going to get another pair of this brand. So here are some things that I don't like but are not outweighed by what I do like:

  • cpa-golfer - Better than expected!!

    I ordered this as a gift, hoping that I would get in a golf bag everything he was wanting. I think I hit the jackpot....I even want to steal this bag for myself! It has the extra putter well, there's slots for every club, there's a grip to load the bag in and out of the vehicle, lots of pockets for easy access, tee storage, and it's a very "pretty" bag!!! Of course, I can't tell a guy it's "pretty", but it is!!! I can't wait for him to open this at Christmas! . . . . . and, by the way, I originally ordered this from a golfing website November 28.....when I still didn't get it on December 15 and never received a reason why, I cancelled the order and found it on Amazon even cheaper than what I had planned on paying, plus got free two-day shipping!! I should have jus ordered through Amazon to begin with!