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Le fluconazole, commercialisé sous le nom de Diflucan, est un antifongique appartenant à la classe des triazolés. Son action repose sur l’inhibition de la 14α-déméthylase dépendante du cytochrome P450, empêchant la conversion du lanostérol en ergostérol, composant essentiel de la membrane fongique. Cette inhibition fragilise la membrane et conduit à la mort cellulaire. La biodisponibilité du fluconazole est élevée (90 %), avec une pénétration efficace dans le liquide céphalorachidien, ce qui justifie son utilisation dans les méningites cryptococciques. Sa demi-vie longue permet des administrations espacées. Les données cliniques soulignent son rôle dans la prise en charge des candidoses systémiques, des candidémies et des infections opportunistes chez les sujets immunodéprimés. Les références thérapeutiques indiquent que diflucan prix est intégré dans de nombreux protocoles, tout en rappelant la surveillance nécessaire des enzymes hépatiques et les interactions avec les substrats du CYP3A4 et du CYP2C9.

UNC Physicians Network - With more than 50 locations and 200 board-certified primary and specialty care physicians, UNC Physicians Network makes quality care accessible for your family.

  • http://www.uncpn.com/uncmc/ UNC Medical Center - Chapel Hill, NC - When you need a hospital, rely on UNC Medical Center in Chapel Hill, NC, to provide you and your family with the latest advances in health care.
  • http://www.uncpn.com/uncmc/unc-childrens/ UNC Children's Hospital - Chapel Hill, NC - When your child needs care, turn to the medical experts at UNC Children's Hospital in Chapel Hill, NC, for compassionate and exemplary health care.
  • http://www.uncpn.com/pn/for-physicians/ For Physicians - Learn more about the benefits for physicians and their practices through UNCPN.
  • http://www.uncpn.com/pn/care-treatment/flu-shots/ Flu Shots | UNC Physicians Network - Get a flu shot from a UNCPN practice today. A flu vaccine can reduce illness, antibiotic use, doctors’ visits and time lost from work and school.
  • http://www.uncpn.com/pn/practices-locations/carolina-advanced-health/ Carolina Advanced Health | Chapel Hill, NC | UNCPN - At Carolina Advanced Health, our on-site care team of doctors, a nutritionist, a pharmacist, a care manager and a behavioral therapist are here for you.
  • http://www.uncpn.com/pn/practices-locations/chapel-hill-internal-medicine Chapel Hill Internal Medicine | Chapel Hill, NC | UNCPN - Chapel Hill Internal Medicine is a multi-specialty practice located in Chapel Hill, NC. We provide a broad spectrum of services for our adult patients.
  • http://www.uncpn.com/pn/about/ About UNC Physicians Network - Learn more about UNC Physicians Network, which provides a full range of primary care and specialty services to people in 13 counties throughout NC.
  • http://www.uncpn.com/pn/careers/ Careers | UNC Physicians Network - High-quality health care begins with high-caliber people. At UNCPN, our steadfast commitment to the health of our community begins within.
  • http://www.uncpn.com/pn/patient-information/medical-home/ Medical Home | UNC Physician's Network - A medical home is a team-based approach to health care. The team is made of health care providers, support staff and most importantly—YOU.

    Country: 149.126.77.121, Europe, DE

    City: 8.6833 Hesse, Germany

  • Sherri Haughton - Ok If You're A Dance Game Person, But Get It On Sale!!

    Really, this game has a lot of potential. However, given the other things available on the market, I had to give it a three star rating.

  • C Anderson - The shoulder strap stayed sturdy and the velcro lasted consistent use

    I used every day this bag while working for 18 months. It wasn't pampered in any fashion, and often found itself in rough conditions. Survived the winter of Virginia, summer of North Carolina and Brazil. Not once did water get into it and damage any material. And believe me, unexpected torrential downpour happens a lot in Brasil. Then ontop of that, it would dry fairly quickly. Often times friends would have books, pamphlets, and papers ruined, while mine were left perfectly dry. The shoulder strap stayed sturdy and the velcro lasted consistent use. It wasn't until 16 months that the front velcro started to fray a little, but it didn't worsen after that. But considering I opened this bag 25+ times a day for 16 months, it's not bad at all. There really is superb quality that comes with any Timbuk2 bag. The inside material held up extremely well. Mine is marked up from mens and other things I've put into the bag, but it never tore or failed in quality. I loved being able to adjust the shoulder strap. Some days while carrying around heavy stuff, it was nice to have it high, and some days it was nice to let it hang lower. It's quick and easy.